Biophotonics Applied to Health Sciences Department, Nove de Julho University (UNINOVE), Vergueiro, 245 São Paulo, Brazil, 01504-001.
Biophotonics Applied to Health Sciences Department, Nove de Julho University (UNINOVE), Vergueiro, 245 São Paulo, Brazil, 01504-001.
Photodiagnosis Photodyn Ther. 2022 Jun;38:102835. doi: 10.1016/j.pdpdt.2022.102835. Epub 2022 Mar 30.
The choice of parameters in Photodynamic Therapy for endodontic treatment, such as wavelength, energy, application time, and number of sessions can vary based on the characteristics of the procedure and the patient. Providing information supported by scientific evidence in an accessible way to clinicians who are unfamiliar with the literature is necessary. Thus, this study aimed to synthesize a clinical protocol for the use of photodynamic therapy in endodontics in permanent teeth.
Protocols with high methodological quality were identified using a literature search and the Appraisal of Guidelines Research and Evaluation Instrument (AGREE II), a validated tool for assessing quality. The recommendations of these studies were synthesized and submitted to a group of experts for evaluation and adaptation, and consensus was assessed using the Delphi methodology.
The analysis of the literature on the application of antimicrobial photodynamic therapy in endodontics showed that clinical trials with good levels of evidence and clinical recommendations have been reported previously, with two studies identified as having a clinical recommendation level of A1A and an evidence level of A.
The written protocol was considered to be satisfactory and as having appropriate content validity during the second round of evaluation by the experts. The studies included in this research were predominantly explanatory in nature, highlighting the need for pragmatic designs to increase the degree of clinical applicability.
光动力疗法在牙髓治疗中的参数选择，如波长、能量、应用时间和治疗次数，可根据治疗过程和患者的特点而有所不同。向不熟悉文献的临床医生提供有科学依据的信息是必要的。因此，本研究旨在综合制定一个关于在恒牙牙髓中使用光动力疗法的临床方案。
使用文献检索和经过验证的评估指南研究和评估工具（AGREE II）来确定具有高方法学质量的方案，该工具用于评估质量。对这些研究的建议进行综合，并提交给一组专家进行评估和调整，使用德尔菲法评估共识。
对牙髓应用抗菌光动力疗法的文献分析表明，先前已经报道了具有良好证据水平和临床推荐的临床试验，有两项研究被确定为具有 A1A 级临床推荐水平和 A 级证据水平。
在专家的第二轮评估中，书面方案被认为是令人满意的，具有适当的内容有效性。本研究纳入的研究主要是解释性的，突出了需要采用实用设计来提高临床适用性程度。
