Huang Shan, Qi Manlin, Chen Yingxue
Department of Stomatology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, China.
Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China.
Front Microbiol. 2023 Feb 10;14:948092. doi: 10.3389/fmicb.2023.948092. eCollection 2023.
Infectious diseases remain a serious global challenge threatening human health. Oral infectious diseases, a major neglected global problem, not only affect people's lifestyles but also have an intimate association with systemic diseases. Antibiotic therapy is a common treatment. However, the emergence of new resistance problems hindered and enhanced the complication of the treatment. Currently, antimicrobial photodynamic therapy (aPDT) has long been the topic of intense interest due to the advantage of being minimally invasive, low toxicity, and high selectivity. aPDT is also becoming increasingly popular and applied in treating oral diseases such as tooth caries, pulpitis, periodontal diseases, peri-implantitis, and oral candidiasis. Photothermal therapy (PTT), another phototherapy, also plays an important role in resisting resistant bacterial and biofilm infections. In this mini-review, we summarize the latest advances in photonics-based treatments of oral infectious diseases. The whole review is divided into three main parts. The first part focuses on photonics-based antibacterial strategies and mechanisms. The second part presents applications for photonics-based treatments of oral infectious diseases. The last part discusses present problems in current materials and future perspectives.
传染病仍然是威胁人类健康的严峻全球挑战。口腔传染病是一个被严重忽视的全球性问题，不仅影响人们的生活方式，还与全身性疾病密切相关。抗生素治疗是一种常见的治疗方法。然而，新的耐药问题的出现阻碍并加剧了治疗的复杂性。目前，抗菌光动力疗法（aPDT）由于具有微创、低毒和高选择性的优点，长期以来一直是人们密切关注的话题。aPDT在治疗龋齿、牙髓炎、牙周病、种植体周围炎和口腔念珠菌病等口腔疾病方面也越来越受欢迎并得到应用。光热疗法（PTT）作为另一种光疗法，在抵抗耐药细菌和生物膜感染方面也发挥着重要作用。在这篇小型综述中，我们总结了基于光子学的口腔传染病治疗的最新进展。整个综述分为三个主要部分。第一部分重点介绍基于光子学的抗菌策略和机制。第二部分介绍基于光子学的口腔传染病治疗的应用。最后一部分讨论当前材料存在的问题和未来展望。
