School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
J Control Release. 2022 May;345:832-850. doi: 10.1016/j.jconrel.2022.03.056. Epub 2022 Mar 31.
The therapeutics based on nanoparticles (NPs) are considered as the promising strategy for tumor detection and treatment. However, one of the most challenges is the adsorption of biomolecules on NPs after their exposition to biological medium, leading unpredictable in vivo behaviors. The interactions caused by protein corona (PC) will influence the biological fate of NPs in either negative or positive ways, including (i) blood circulation, accumulation and penetration of NPs at targeting sites, and further cellular uptake in tumor targeting delivery; (ii) interactions between NPs and receptors on immune cells for immunotherapy. Besides, PC on NPs could be utilized as new biomarker in tumor diagnosis by identifying the minor change of protein concentration led by tumor growth and invasion in blood. Herein, the mechanisms of these PC-mediated effects will be introduced. Moreover, the recent advances about the strategies will be reviewed to reduce negative effects caused by PC and/or utilize positive effects of PC on tumor targeting, immunotherapy and diagnosis, aiming to provide a reasonable perspective to recognize PC with their applications.
基于纳米粒子（NPs）的治疗方法被认为是肿瘤检测和治疗的有前途的策略。然而，最具挑战性的问题之一是 NPs 在暴露于生物介质后，生物分子在 NPs 上的吸附，导致不可预测的体内行为。蛋白质冠（PC）引起的相互作用将以负面或正面的方式影响 NPs 的生物学命运，包括：（i） NPs 在靶向部位的血液循环、积累和穿透，以及在肿瘤靶向递药中的进一步细胞摄取；（ii） NPs 与免疫细胞上的受体之间的相互作用，用于免疫治疗。此外，NPs 上的 PC 可作为肿瘤诊断的新生物标志物，通过识别肿瘤生长和入侵血液引起的蛋白质浓度的微小变化。本文将介绍这些 PC 介导的作用机制。此外，还将回顾最近关于这些策略的进展，以减少 PC 引起的负面影响和/或利用 PC 对肿瘤靶向、免疫治疗和诊断的积极作用，旨在为认识 PC 及其应用提供合理的视角。
