Lang J M, Gastaut J A, Sotto J J, Troncy J, Marchiani C
Int J Immunopharmacol. 1986;8(7):687-90. doi: 10.1016/0192-0561(86)90003-2.
RU 41740 (Biostim) is a glycoprotein extract from Klebsiella pneumoniae with immunostimulating properties in animal studies and in in vitro assays of human leukocyte functions. The present randomized double blind phase II trial showed that RU 41740 significantly (P less than 0.05, Mann & Whitney test) enhanced delayed cutaneous hypersensitivity to seven recall antigens (Multitest system) in lymphoma patients in unmaintained complete remission when given orally for 14 days at a daily dose of 8 mg, and compared to placebo. Daily doses of 2 and 32 mg were uneffective.
RU 41740（生物刺激素）是一种从肺炎克雷伯菌中提取的糖蛋白，在动物研究和人体白细胞功能的体外试验中具有免疫刺激特性。目前这项随机双盲II期试验表明，对于处于未维持完全缓解状态的淋巴瘤患者，当每天口服8毫克，持续14天时，RU 41740与安慰剂相比，能显著（P<0.05，Mann & Whitney检验）增强对七种回忆抗原（多试验系统）的迟发型皮肤超敏反应。每日剂量为2毫克和32毫克时无效。
