非碱性糖苷酶抑制剂的最新研究成果：结构多样性如何为提高抑制效力的通用策略提供信息。
Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency.
作者信息
Simone Michela I, Wood Adam, Campkin David, Kiefel Milton J, Houston Todd A
机构信息
Discipline of Chemistry, University of Newcastle, Callaghan, NSW, 2308, Australia; Priority Research Centre for Drug Design, University of Newcastle, Callaghan, NSW, 2308, Australia.
Discipline of Chemistry, University of Newcastle, Callaghan, NSW, 2308, Australia; Priority Research Centre for Drug Design, University of Newcastle, Callaghan, NSW, 2308, Australia.
出版信息
Eur J Med Chem. 2022 May 5;235:114282. doi: 10.1016/j.ejmech.2022.114282. Epub 2022 Mar 20.
This review covers the literature in the past 15 years on glycosidase inhibitors lacking a basic nitrogen (for example iminosugars/azasugars) with a focus on natural terpenoids, and mono- and polycyclic aromatic hydrocarbons. From quite diverse structures, insight into inhibitor structural features that may be applicable to optimisation of all glycosidase inhibitors including iminosugars are identified.
本综述涵盖了过去15年中关于不含碱性氮的糖苷酶抑制剂（例如亚氨基糖/氮杂糖）的文献，重点关注天然萜类化合物以及单环和多环芳烃。从多种多样的结构中，确定了可能适用于包括亚氨基糖在内的所有糖苷酶抑制剂优化的抑制剂结构特征。
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