Nistor Oana-Irina, Godfrey Christina, Ross-White Amanda, Wilson Rosemary
Faculty of Health Sciences, School of Nursing, Queen's University, Kingston, Ontario, Canada.
J Can Assoc Gastroenterol. 2021 Nov 14;5(2):96-97. doi: 10.1093/jcag/gwab043. eCollection 2022 Apr.
The symptom burden in inflammatory bowel disease (IBD) has a significant negative impact on the health-related quality of life (HRQOL). Patients with IBD report physical, psychological and social discomfort even during remission.
To synthesize the best available evidence to determine the worldwide incidence, prevalence and determinants of discomfort in adults with inflammatory bowel disease (IBD).
Following PRISMA recommendations, we searched the Medline, CINAHL, PsycInfo, Embase, Cochrane, Campbell and JBI Evidence Synthesis databases for studies on either incidence or prevalence of discomfort in English until January 2021. Data were extracted using the Joanna Briggs Institute's standardized extraction tools. Data that directly reported or could be used to calculate the incidence and prevalence of discomfort were extracted. Ten studies were eligible for inclusion in this review. Overall, the methodological quality of the included studies was considered moderate. Data measuring the incidence of discomfort in 6 out of 10 identified studies using the same measurement tool (EQ-5D) were pooled in a meta-analysis. Additional results have been presented in a narrative form, including tables.
There is no standardized definition or tool utilized to describe or measure discomfort in IBD. Synthesized findings demonstrate that discomfort is prevalent among adults living with IBD. Determinants of discomfort included health literacy, disease activity, hospitalization/surgery, age and gender, delayed diagnosis, local practice standards and quality of IBD care.
More research is needed to identify the impact of discomfort on health-related outcomes for people with IBD and consequently appraise discomfort interventions for their efficacy.
炎症性肠病（IBD）的症状负担对健康相关生活质量（HRQOL）有显著负面影响。即使在缓解期，IBD患者也会出现身体、心理和社会方面的不适。
综合现有最佳证据，以确定全球范围内成年炎症性肠病（IBD）患者不适的发病率、患病率及决定因素。
按照PRISMA指南，我们检索了Medline、CINAHL、PsycInfo、Embase、Cochrane、Campbell和JBI证据综合数据库，查找截至2021年1月的英文关于不适发病率或患病率的研究。使用乔安娜·布里格斯研究所的标准化提取工具提取数据。提取直接报告或可用于计算不适发病率和患病率的数据。十项研究符合纳入本综述的条件。总体而言，纳入研究的方法学质量被认为中等。使用相同测量工具（EQ-5D）的10项已识别研究中的6项测量不适发病率的数据被纳入荟萃分析。其他结果以叙述形式呈现，包括表格。
目前尚无用于描述或测量IBD患者不适的标准化定义或工具。综合研究结果表明，不适在IBD成年患者中普遍存在。不适的决定因素包括健康素养、疾病活动度、住院/手术、年龄和性别、诊断延迟、当地实践标准以及IBD护理质量。
需要更多研究来确定不适对IBD患者健康相关结局的影响，并因此评估不适干预措施的疗效。
