Antipova Christina G, Parunova Yulia M, Vishnevskaya Maria V, Krasheninnikov Sergey V, Lukanina Ksenia I, Grigoriev Timofei E, Chvalun Sergei N, Gotovtsev Pavel M
National Research Centre "Kurchatov Institute", Department of Nanobiomaterials and Structures, Akademika Kurchatova pl., 1, 123182, Moscow, Russia.
National Research Centre "Kurchatov Institute", Biotechnology and Bioenergy Department, Akademika Kurchatova pl., 1, 123182, Moscow, Russia.
Heliyon. 2022 Mar 29;8(3):e09218. doi: 10.1016/j.heliyon.2022.e09218. eCollection 2022 Mar.
The possibility of creating a biofuel cell based on a metal stent was shown in this study. Given the existing stent implantation approaches, the integration of a biofuel cell into a stent naturally entails capacity for biofuel cells to be installed into a human body. As a counter electrode, a hydrogel based on iota-carrageenan, polyvinyl alcohol, and PEDOT:PSS, with an immobilized glucose oxidase enzyme, was proposed. Tension tests demonstrated that the hydrogel mechanical behavior resembles that of a bovine's vein. To obtain an analytical description, the deformation curves were fitted using Gent and Ogden models, prompting the fitting parameters which can be useful in further investigations. During cyclic biaxial studies the samples strength was shown to decreases insignificantly in the first 50 cycles and, further, remains stable up to more than 100 cycles. The biofuel cell was designed with the PEDOT:PSS based material as an anode and a Co-Cr self-expanding stent as a cathode. The maximum biofuel cell power density with a glucose concentration of 5 mM was 7.87 × 10 W in phosphate buffer and 3.98 × 10 W in blood mimicking buffer. Thus, the biofuel cell integration in the self-expanding stent was demonstrated.
本研究展示了基于金属支架制造生物燃料电池的可能性。鉴于现有的支架植入方法，将生物燃料电池集成到支架中自然意味着生物燃料电池有能力被安装到人体中。作为对电极，提出了一种基于ι-卡拉胶、聚乙烯醇和PEDOT:PSS的水凝胶，并固定了葡萄糖氧化酶。拉伸试验表明，水凝胶的力学行为类似于牛静脉。为了获得分析描述，使用Gent模型和Ogden模型对变形曲线进行拟合，得出了在进一步研究中可能有用的拟合参数。在循环双轴研究中，样品强度在前50个循环中略有下降，此后，在超过100个循环中保持稳定。该生物燃料电池设计为以基于PEDOT:PSS的材料为阳极，以钴铬自膨胀支架为阴极。在磷酸盐缓冲液中，葡萄糖浓度为5 mM时，生物燃料电池的最大功率密度为7.87×10 W，在模拟血液缓冲液中为3.98×10 W。因此，证明了生物燃料电池可集成到自膨胀支架中。
