DeVito Elise E, Fagle Tessa, Allen Alicia M, Pang Raina D, Petersen Nicole, Smith Philip H, Weinberger Andrea H
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Department of Family and Community Medicine, College of Medicine - Tucson, University of Arizona, Tucson, AZ, USA.
Curr Addict Rep. 2021 Sep;8(3):366-379. doi: 10.1007/s40429-021-00381-9. Epub 2021 Jul 21.
This review examines the risk of adverse perinatal outcomes following electronic nicotine delivery system (ENDS) use during pregnancy, and considers whether there are sufficient data to support ENDS as a harm reduction approach during pregnancy.
Seven papers assessed perinatal outcomes following ENDS use during pregnancy. There was evidence that ENDS use was associated with increased risk for some adverse perinatal outcomes (e.g., small for gestational age). However, the repeated use of data sets, insufficient data (e.g., timing of ENDS use, type of ENDS products used), and limited samples size, contributed to mixed findings on the degree to which ENDS use (alone or in combination with combustible cigarettes (CC)) impacts the risk of adverse perinatal outcomes relative to CC smoking alone.
The current data are still insufficient to support ENDS as a harm reduction approach, though findings do warrant concern and more detailed investigation of ENDS use during pregnancy. Future research directions, as well as implications for clinical recommendations and tobacco regulatory science are discussed.
本综述探讨孕期使用电子尼古丁传送系统（ENDS）后不良围产期结局的风险，并考量是否有足够数据支持ENDS作为孕期减少危害的方法。
七篇论文评估了孕期使用ENDS后的围产期结局。有证据表明，使用ENDS与某些不良围产期结局风险增加有关（如小于胎龄儿）。然而，数据集的重复使用、数据不足（如ENDS使用时间、所使用的ENDS产品类型）以及样本量有限，导致关于ENDS使用（单独或与可燃香烟（CC）联合使用）相对于单独吸CC对不良围产期结局风险影响程度的研究结果不一。
目前的数据仍不足以支持将ENDS作为减少危害的方法，尽管研究结果确实值得关注，并需对孕期使用ENDS进行更详细的调查。本文讨论了未来的研究方向以及对临床建议和烟草监管科学的影响。
