心血管疾病中的脂质与脂蛋白：一种分类

Lipids and lipoproteins in cardiovascular diseases: a classification.

作者信息

Bhargava Shruti, de la Puente-Secades Sofia, Schurgers Leon, Jankowski Joachim

机构信息

Institute of Molecular Cardiovascular Research, Medical Faculty, RWTH Aachen University, Aachen, Germany; Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands.

Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands.

出版信息

Trends Endocrinol Metab. 2022 Jun;33(6):409-423. doi: 10.1016/j.tem.2022.02.001. Epub 2022 Mar 31.

DOI:10.1016/j.tem.2022.02.001

PMID:35370062

Abstract

Lipids and lipoproteins, their metabolism, and their transport are essential contributing factors of cardiovascular disease (CVD) as they regulate plasma cholesterol concentration, enhancing cholesterol uptake by macrophages, leading to foam cell formation and ultimately resulting in plaque formation and inflammation. However, lipids and lipoproteins have cardioprotective functions as well, such as preventing oxidation of proatherogenic molecules and downregulating inflammatory proteins.

摘要

脂质和脂蛋白、它们的代谢及转运是心血管疾病（CVD）的重要促成因素，因为它们调节血浆胆固醇浓度，增强巨噬细胞对胆固醇的摄取，导致泡沫细胞形成，并最终导致斑块形成和炎症。然而，脂质和脂蛋白也具有心脏保护功能，例如防止促动脉粥样硬化分子的氧化和下调炎症蛋白。