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抗生素智能医学影像增强抗菌作用及耐药机制研究

Mechanism of Antibacterial Enhancement and Drug Resistance Based on Smart Medical Imaging on Antibiotics.

机构信息

College of Food Science and Project Engineering, Shandong Agriculture and Engineering University, Jinan, 250100 Shandong, China.

出版信息

Comput Math Methods Med. 2022 Mar 23;2022:6103649. doi: 10.1155/2022/6103649. eCollection 2022.

Abstract

With the development of antibacterial, synergistic, and drug resistance research, the requirements for the specificity of antibiotics are getting higher and higher. In the research based on the specificity of antibiotics, this article uses intelligent medical image processing methods to study the specificity of the antibacterial efficiency of nanocopper oxide and the inhibition of drug resistance. Copper oxide nanorods have the properties of surface effect, quantum size effect, volume effect, and macroscopic quantum tunneling effect. Compared with ordinary copper oxide, the nanoscale gives them special properties of electricity, optics, and catalysis. In this article, in the research based on the specificity of antibiotics, the specificity of antimicrobial efficiency and drug resistance inhibition of nanocopper oxide are studied by using smart medical information processing methods. Drug sensitivity paper tablet method is a drug sensitivity experiment to determine drug sensitivity to make accurate and effective use of drugs for treatment. Colony growth method is used to take the equivalent volume of fermentation liquid at different times to determine the content of bacteria. In this article, Staphylococcus aureus is cultivated by the drug-sensitive disk method and the colony growth method. Then, according to this type of antibiotic and bacterial group combination, Staphylococcus aureus is divided into a penicillin group, nanocopper oxide group, and cephalosporin group. 0.5 g of the corresponding antibiotic was added to each group. TMP (trimethoprim) acts as a synergist, and the ratio of TMP to antibiotic is 1 : 5. Finally, we compared the inhibitory concentration indexes of the above three groups and inferred the synergistic effect of antibiotics and the inhibitory effect of drug resistance through the specificity of the antibiotics that the antibacterial activity was further studied. The results showed that the antibacterial effect of TMP combined with nano-CuO was 38% higher than that of the penicillin group and 41% higher than that of the cephalosporin group. In addition, the combined effect of TMP and antibiotics is greater than the combined effect of TMP and antibiotics alone. From the observation of smart medical system processing, it is speculated that the reason may be that they provide each other with a suitable environment. Because of this combined effect between the TMP and the antibiotic, it can influence each other. From the results, the combined effect is 48% higher than the combined effect. Therefore, according to the results of medical imaging, the combination of antibiotics and antibacterial synergists can improve specificity and antibacterial rate.

摘要

随着抗菌、协同和耐药性研究的发展,对抗生素特异性的要求越来越高。在基于抗生素特异性的研究中,本文采用智能医学图像处理方法研究纳米氧化铜的抗菌效率特异性和耐药性抑制。氧化铜纳米棒具有表面效应、量子尺寸效应、体积效应和宏观量子隧道效应。与普通氧化铜相比,纳米尺度赋予了它们特殊的电学、光学和催化性能。在本文中,在基于抗生素特异性的研究中,采用智能医学信息处理方法研究纳米氧化铜的抗菌效率特异性和耐药性抑制。药敏纸片法是一种药敏实验,旨在确定药物敏感性,以便为治疗做出准确有效的药物使用。集落生长法用于在不同时间取等量发酵液,以确定细菌含量。在本文中,采用药敏纸片法和集落生长法培养金黄色葡萄球菌。然后,根据这种抗生素和细菌组合类型,将金黄色葡萄球菌分为青霉素组、纳米氧化铜组和头孢菌素组。每组加入 0.5g 相应的抗生素。TMP(甲氧苄啶)作为协同剂,TMP 与抗生素的比例为 1:5。最后,我们比较了三组的抑菌浓度指数,并通过抗生素的特异性推断抗生素的协同作用和耐药性抑制作用,进一步研究了抗生素的抗菌活性。结果表明,TMP 与纳米-CuO 联合使用的抗菌效果比青霉素组高 38%,比头孢菌素组高 41%。此外,TMP 与抗生素联合使用的效果大于 TMP 与抗生素单独联合使用的效果。从智能医疗系统处理的观察来看,推测原因可能是它们为彼此提供了一个合适的环境。由于这种 TMP 和抗生素之间的联合作用,它们可以相互影响。从结果来看,联合效果比单独使用时提高了 48%。因此,根据医学成像的结果,抗生素和抗菌增效剂的联合使用可以提高特异性和抗菌率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a09e/8967524/c3ec76f3b666/CMMM2022-6103649.001.jpg

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