黄酮类化合物的伤口愈合特性：系统评价强调作用机制。

Wound healing properties of flavonoids: A systematic review highlighting the mechanisms of action.

机构信息

Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, Marechal Rondon Avenue, S/N, Rosa Elza, CEP: 49.000-100, São Cristóvão, SE, Brazil; Health Sciences Graduate Program (PPGCS), Federal University of Sergipe, São Cristóvão, SE, Brazil.

出版信息

Phytomedicine. 2021 Sep;90:153636. doi: 10.1016/j.phymed.2021.153636. Epub 2021 Jun 19.

DOI:10.1016/j.phymed.2021.153636

PMID:34333340

Abstract

BACKGROUND

Flavonoids are a class of compounds with a wide variety of biological functions, being an important source of new products with pharmaceutical potential, including treatment of skin wounds.

PURPOSE

This review aimed to summarize and evaluate the evidence in the literature in respect of the healing properties of flavonoids on skin wounds in animal models.

STUDY DESIGN

This is a systematic review following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.

METHODS

This was carried out through a specialized search of four databases: PubMed, Scopus, Web of Science and Embase. The following keyword combinations were used: "flavonoidal" OR "flavonoid" OR "flavonoidic" OR "flavonoids" AND "wound healing" as well as MeSH terms, Emtree terms and free-text words.

RESULTS

Fifty-five (55) articles met the established inclusion and exclusion criteria. Flavonoids presented effects in respect of the inflammatory process, angiogenesis, re-epithelialization and oxidative stress. They were shown to be able to act on macrophages, fibroblasts and endothelial cells by mediating the release and expression of TGF-β1, VEGF, Ang, Tie, Smad 2 and 3, and IL-10. Moreover, they were able to reduce the release of inflammatory cytokines, NFκB, ROS and the M1 phenotype. Flavonoids acted by positively regulating MMPs 2, 8, 9 and 13, and the Ras/Raf/MEK/ERK, PI3K/Akt and NO pathways.

CONCLUSION

Flavonoids are useful tools in the development of therapies to treat skin lesions, and our review provides a scientific basis for future basic and translational research.

摘要

背景

类黄酮是一类具有广泛生物功能的化合物，是具有药物潜力的新产品的重要来源，包括治疗皮肤伤口。

目的

本综述旨在总结和评估文献中关于类黄酮在动物模型皮肤伤口愈合特性的证据。

研究设计

这是一项遵循系统评价和荟萃分析 (PRISMA) 报告指南的系统评价。

方法

通过专门搜索四个数据库进行了这项研究：PubMed、Scopus、Web of Science 和 Embase。使用了以下关键词组合：“flavonoidal”或“flavonoid”或“flavonoidic”或“flavonoids”和“wound healing”以及 MeSH 术语、Emtree 术语和自由文本词。

结果

符合既定纳入和排除标准的文章有 55 篇。类黄酮在炎症过程、血管生成、再上皮化和氧化应激方面表现出效果。它们被证明能够通过介导 TGF-β1、VEGF、Ang、Tie、Smad 2 和 3 以及 IL-10 的释放和表达，作用于巨噬细胞、成纤维细胞和内皮细胞。此外，它们能够减少炎症细胞因子、NFκB、ROS 和 M1 表型的释放。类黄酮通过正向调节 MMPs 2、8、9 和 13，以及 Ras/Raf/MEK/ERK、PI3K/Akt 和 NO 途径发挥作用。