新生儿心律失常与死亡率及复发之间的关联：一项回顾性研究。
Association Between Neonatal Arrhythmia and Mortality and Recurrence: A Retrospective Study.
作者信息
Ran Lihong, Li Jie, Bao Lei, Chen Long
机构信息
Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Chongqing Key Laboratory of Pediatrics, Chongqing, China.
出版信息
Front Pediatr. 2022 Mar 11;10:818164. doi: 10.3389/fped.2022.818164. eCollection 2022.
OBJECTIVE
The aim of the present study was to explore the association between neonatal arrhythmia (NA) and mortality and recurrence.
METHODS
A single-center, retrospective study was performed between January 1, 2015, and December 31, 2019. Neonates with NA were eligible and divided into either benign or non-benign groups. The primary outcomes were mortality and recurrence within 2 to 6 years.
RESULTS
NA was diagnosed in 189 patients (0.39%) after screening 47,911 hospitalized neonates, and 10 of them did not finish the follow-up. Finally, 179 neonates were included into the final analysis (58 in the non-benign NA and 121 in the benign NA groups). The incidences of death and recurrence for NA were 5.59% (10/179) and 18.44% (33/179). Compared with neonates with benign NA, those neonates with non-benign NA were shown higher rates of death (13.79% vs. 1.65%; odds ratio [OR], 5.73; 95% confidence interval [CI], 1.07-31.01; = 0.04) and recurrence (44.83% vs. 5.79%; OR, 8.49; 95% CI, 3.12-23.08; < 0.001).
CONCLUSIONS
Neonates with non-benign NA were shown higher rates of death and recurrence when compared with benign NA. Because of high recurrence, more attention was needed in neonates with non-benign NA after discharge.
目的
本研究旨在探讨新生儿心律失常（NA）与死亡率及复发之间的关联。
方法
于2015年1月1日至2019年12月31日进行了一项单中心回顾性研究。纳入患有NA的新生儿，并将其分为良性或非良性组。主要结局为2至6年内的死亡率和复发率。
结果
在筛查47911例住院新生儿后，189例（0.39%）被诊断为NA，其中10例未完成随访。最终，179例新生儿纳入最终分析（非良性NA组58例，良性NA组121例）。NA的死亡率和复发率分别为5.59%（10/179）和18.44%（33/179）。与良性NA新生儿相比，非良性NA新生儿的死亡率（13.79%对1.65%；优势比[OR]，5.73；95%置信区间[CI]，1.07 - 31.01；P = 0.04）和复发率（44.83%对5.79%；OR，8.49；95%CI，3.12 - 23.08；P < 0.001）更高。
结论
与良性NA相比，非良性NA新生儿的死亡率和复发率更高。由于复发率高，非良性NA新生儿出院后需要更多关注。
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