Kazemzadeh Parya, Sayadi Khalil, Toolabi Ali, Sayadi Jalil, Zeraati Malihe, Chauhan Narendra Pal Singh, Sargazi Ghasem
Department of Chemistry, Lorestan University, Khorramabad, Iran.
Department of Chemistry, Young Researchers Society, Shahid Bahonar University of Kerman, Kerman, Iran.
Front Chem. 2022 Mar 14;10:823785. doi: 10.3389/fchem.2022.823785. eCollection 2022.
Mesoporous silica nanoparticles (MSNs) are widely used as a promising candidate for drug delivery applications due to silica's favorable biocompatibility, thermal stability, and chemical properties. Silica's unique mesoporous structure allows for effective drug loading and controlled release at the target site. In this review, we have discussed various methods of MSNs' mechanism, properties, and its drug delivery applications. As a result, we came to the conclusion that more biocompatibility studies, toxicity studies, bio-distribution studies and clinical research are essential for MSN advancement.
介孔二氧化硅纳米颗粒（MSNs）因其良好的生物相容性、热稳定性和化学性质，作为药物递送应用的一个有前途的候选者而被广泛使用。二氧化硅独特的介孔结构允许在靶位点进行有效的药物负载和控释。在这篇综述中，我们讨论了MSNs的作用机制、性质及其药物递送应用的各种方法。因此，我们得出结论，更多的生物相容性研究、毒性研究、生物分布研究和临床研究对于MSN的发展至关重要。
