Wang Qiuxiang, Liu Songlin, Lu Wenjuan, Zhang Pingping
School of Pharmacy & Pharmaceutical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Front Chem. 2022 Mar 16;10:870666. doi: 10.3389/fchem.2022.870666. eCollection 2022.
The core/shell structure nanofiber membrane loaded with curcumin and silver nanoparticles was prepared by coaxial electrospinning technology, which is a high-efficiency combined antibacterial material composed of photodynamic antibacterial agent and metal nanoparticle. As a photosensitizer, curcumin could generate singlet oxygen under laser irradiation. Silver nanoparticles have antibacterial properties, and could also enhance the singlet oxygen production of curcumin due to the metal-enhanced singlet oxygen effect, thereby producing a synergistic antibacterial effect. Compared with the antibacterial rate of uniaxial curcumin fiber membrane (45.65%) and uniaxial silver nanoparticle-loaded fiber membrane (66.96%), the antibacterial rate of curcumin@Ag core/shell structure fiber membrane against is as high as 93.04%. In addition, the antibacterial experiments show that the core/shell fiber membrane also has excellent antibacterial effects on .
采用同轴静电纺丝技术制备了负载姜黄素和银纳米颗粒的核/壳结构纳米纤维膜，它是一种由光动力抗菌剂和金属纳米颗粒组成的高效复合抗菌材料。姜黄素作为光敏剂，在激光照射下可产生单线态氧。银纳米颗粒具有抗菌性能，并且由于金属增强单线态氧效应还可增强姜黄素的单线态氧生成，从而产生协同抗菌作用。与单轴姜黄素纤维膜（45.65%）和单轴负载银纳米颗粒纤维膜（66.96%）的抗菌率相比，姜黄素@银核/壳结构纤维膜对……的抗菌率高达93.04%。此外，抗菌实验表明核/壳纤维膜对……也具有优异的抗菌效果。
