Díaz-Puertas Rocío, Álvarez-Martínez Francisco Javier, Falco Alberto, Barrajón-Catalán Enrique, Mallavia Ricardo
Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández (UMH), 03202 Elche, Spain.
Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), 03010 Alicante, Spain.
Polymers (Basel). 2023 Mar 10;15(6):1392. doi: 10.3390/polym15061392.
Antibiotic-resistant bacteria (ARB) is a growing global health threat, leading to the search for alternative strategies to combat bacterial infections. Phytochemicals, which are naturally occurring compounds found in plants, have shown potential as antimicrobial agents; however, therapy with these agents has certain limitations. The use of nanotechnology combined with antibacterial phytochemicals could help achieve greater antibacterial capacity against ARB by providing improved mechanical, physicochemical, biopharmaceutical, bioavailability, morphological or release properties. This review aims to provide an updated overview of the current state of research on the use of phytochemical-based nanomaterials for the treatment against ARB, with a special focus on polymeric nanofibers and nanoparticles. The review discusses the various types of phytochemicals that have been incorporated into different nanomaterials, the methods used to synthesize these materials, and the results of studies evaluating their antimicrobial activity. The challenges and limitations of using phytochemical-based nanomaterials, as well as future directions for research in this field, are also considered here. Overall, this review highlights the potential of phytochemical-based nanomaterials as a promising strategy for the treatment against ARB, but also stresses the need for further studies to fully understand their mechanisms of action and optimize their use in clinical settings.
抗生素耐药菌（ARB）对全球健康构成的威胁日益严重，这促使人们寻找对抗细菌感染的替代策略。植物化学物质是植物中天然存在的化合物，已显示出作为抗菌剂的潜力；然而，使用这些物质进行治疗存在一定局限性。将纳米技术与抗菌植物化学物质相结合，通过提供改进的机械、物理化学、生物制药、生物利用度、形态或释放特性，有助于实现对ARB更强的抗菌能力。本综述旨在提供基于植物化学物质的纳米材料用于治疗ARB的研究现状的最新概述，特别关注聚合物纳米纤维和纳米颗粒。该综述讨论了已被纳入不同纳米材料的各类植物化学物质、合成这些材料所采用的方法，以及评估其抗菌活性的研究结果。本文还考虑了使用基于植物化学物质的纳米材料所面临的挑战和局限性，以及该领域未来的研究方向。总体而言，本综述强调了基于植物化学物质的纳米材料作为治疗ARB的一种有前景策略的潜力，但同时也强调需要进一步研究以充分了解其作用机制，并在临床环境中优化其使用。
