Wei Yuanfeng, Gao Limin, Yang Xi, Xiang Xiaoyu, Yi Cheng
Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Department of Pathology, West China Hospital, Sichuan University, Chengdu, China.
Front Med (Lausanne). 2022 Mar 16;9:801647. doi: 10.3389/fmed.2022.801647. eCollection 2022.
Gastric cancer (GC) is a typical inflammatory-related malignant tumor which is closely related to helicobacter pylori infection. Tumor inflammatory microenvironment plays a crucial role in tumor progression and affect the clinical benefit from immunotherapy. In recent years, immunotherapy for gastric cancer has achieved promising outcomes, but not all patients can benefit from immunotherapy due to tumor heterogeneity. In our study, we identified 29 differentially expressed and prognostic inflammation-related genes in GC and normal samples. Based on those genes, we constructed a prognostic model using a least absolute shrinkage and selection operator (LASSO) algorithm, which categorized patients with GC into two groups. The high-risk group have the characteristics of "cold tumor" and have a poorer prognosis. In contrast, low-risk group was "hot tumor" and had better prognosis. Targeting inflammatory-related genes and remodeling tumor microenvironment to turn "cold tumor" into "hot tumor" may be a promising solution to improve the efficacy of immunotherapy for patients with GC.
胃癌（GC）是一种典型的炎症相关恶性肿瘤，与幽门螺杆菌感染密切相关。肿瘤炎症微环境在肿瘤进展中起关键作用，并影响免疫治疗的临床疗效。近年来，胃癌免疫治疗取得了令人鼓舞的成果，但由于肿瘤异质性，并非所有患者都能从免疫治疗中获益。在我们的研究中，我们在GC和正常样本中鉴定出29个差异表达且与预后相关的炎症相关基因。基于这些基因，我们使用最小绝对收缩和选择算子（LASSO）算法构建了一个预后模型，该模型将GC患者分为两组。高危组具有“冷肿瘤”特征，预后较差。相比之下，低危组为“热肿瘤”，预后较好。靶向炎症相关基因并重塑肿瘤微环境，将“冷肿瘤”转变为“热肿瘤”，可能是提高GC患者免疫治疗疗效的一个有前景的解决方案。
