Hussain Riaz, Guangbin Zhang, Abbas Rao Zahid, Siddique Abu Baker, Mohiuddin Mudassar, Khan Iahtasham, Rehman Tauseef Ur, Khan Ahrar
Department of Pathology, Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Shandong Vocational Animal Science and Veterinary College, Weifang, China.
Front Vet Sci. 2022 Mar 18;9:849856. doi: 10.3389/fvets.2022.849856. eCollection 2022.
Enterotoxemia is a severe and peracute disease caused by () rendering high mortality leading to huge economic losses, especially in small ruminants. The bacterium induces peracute death in animals based on the rapid production of different lethal toxins. Mortality occurred three private herds of two breeds, i.e., Makhi Cheeni and Beetal, and one non-descriptive (Teddy) herds reared in the desert area of Bahawalpur, Pakistan. At necropsy, tissue samples for histopathology and intestinal contents for bacterial isolation and culture were collected. Following the standard procedure, tissue slides were prepared. Multiplex PCR was used to identify toxinotypes using specific primers. Morbidity, mortality, and case fatality in Makhi Cheeni, Beetal, and Teddy goats caused by enterotoxemia were 87.58, 75.81, and 76.11%, respectively. Based on toxinotypes in the present outbreaks, type A (α = 20.7%; α + β2 = 11.2%) and type D (α + β2 + = 47.7%; α + = 20.7%) were detected. Deaths due to type D (68.10%) were significantly higher ( < 0.001) compared with deaths by type A (34.90%). Petechiation of serosal surfaces, hemorrhage of intestines, lungs, and liver were seen. Kidneys were soft, and under the microscope, tubules were studded with erythrocytes. There was stunting and fusion in the intestinal villi. From this study, we concluded that endotoxemia can occur in any season; thus, a proper vaccination schedule must be followed for the protection of small ruminants' health.
肠毒血症是一种由（）引起的严重且超急性疾病，死亡率很高，会导致巨大的经济损失，尤其是在小型反刍动物中。这种细菌基于快速产生不同的致命毒素而导致动物超急性死亡。在巴基斯坦巴哈瓦尔布尔沙漠地区饲养的两个品种（即Makhi Cheeni和Beetal）的三个私人畜群以及一个无特定品种（Teddy）的畜群中发生了死亡情况。尸检时，采集了用于组织病理学检查的组织样本和用于细菌分离培养的肠道内容物。按照标准程序制备了组织切片。使用多重聚合酶链反应（Multiplex PCR）通过特异性引物鉴定毒素型。由肠毒血症引起的Makhi Cheeni、Beetal和Teddy山羊的发病率、死亡率和病死率分别为87.58%、75.81%和76.11%。基于本次疫情中的毒素型，检测到了A型（α = 20.7%；α + β2 = 11.2%）和D型（α + β2 + = 47.7%；α + = 20.7%）。与A型（34.90%）导致的死亡相比，D型导致的死亡（68.10%）显著更高（< 0.001）。观察到浆膜表面有瘀点、肠道、肺和肝脏出血。肾脏柔软，在显微镜下，肾小管中布满红细胞。肠绒毛有发育迟缓并融合的现象。从这项研究中，我们得出结论，肠毒血症可在任何季节发生；因此，必须遵循适当的疫苗接种计划以保护小型反刍动物的健康。
