Mir Mariam, Ali Murtaza Najabat, Barakullah Afifa, Gulzar Ayesha, Arshad Munam, Fatima Shizza, Asad Maliha
Biomedical Engineering and Sciences Department, School of Mechanical and Manufacturing Engineering (SMME), National University of Sciences and Technology (NUST), Sector H-12, Islamabad, Pakistan.
Prog Biomater. 2018 Mar;7(1):1-21. doi: 10.1007/s40204-018-0083-4. Epub 2018 Feb 14.
Wounds are of a variety of types and each category has its own distinctive healing requirements. This realization has spurred the development of a myriad of wound dressings, each with specific characteristics. It is unrealistic to expect a singular dressing to embrace all characteristics that would fulfill generic needs for wound healing. However, each dressing may approach the ideal requirements by deviating from the 'one size fits all approach', if it conforms strictly to the specifications of the wound and the patient. Indeed, a functional wound dressing should achieve healing of the wound with minimal time and cost expenditures. This article offers an insight into several different types of polymeric materials clinically used in wound dressings and the events taking place at cellular level, which aid the process of healing, while the biomaterial dressing interacts with the body tissue. Hence, the significance of using synthetic polymer films, foam dressings, hydrocolloids, alginate dressings, and hydrogels has been reviewed, and the properties of these materials that conform to wound-healing requirements have been explored. A special section on bioactive dressings and bioengineered skin substitutes that play an active part in healing process has been re-examined in this work.
伤口有多种类型，每一类都有其独特的愈合需求。这一认识促使了无数种伤口敷料的开发，每种敷料都有特定的特性。期望有一种单一的敷料具备满足伤口愈合一般需求的所有特性是不现实的。然而，如果每种敷料严格符合伤口和患者的规格，通过偏离“一刀切”的方法，可能会接近理想要求。事实上，一种功能性伤口敷料应以最少的时间和成本支出实现伤口愈合。本文深入探讨了临床上用于伤口敷料的几种不同类型的聚合物材料，以及在细胞水平上发生的有助于愈合过程的事件，同时生物材料敷料与身体组织相互作用。因此，综述了使用合成聚合物薄膜、泡沫敷料、水胶体、藻酸盐敷料和水凝胶的意义，并探讨了这些材料符合伤口愈合要求的特性。在这项工作中，重新审视了在愈合过程中发挥积极作用的生物活性敷料和生物工程皮肤替代品的一个特别章节。
