从大肠杆菌tRNA中分离出的一种核苷Q前体的结构测定：7-(氨甲基)-7-脱氮鸟苷。
Structure determination of a nucleoside Q precursor isolated from E. coli tRNA: 7-(aminomethyl)-7-deazaguanosine.
作者信息
Okada N, Noguchi S, Nishimura S, Ohgi T, Goto T, Crain P F, McCloskey J A
出版信息
Nucleic Acids Res. 1978 Jul;5(7):2289-96. doi: 10.1093/nar/5.7.2289.
Abstract
A precursor of modified nucleoside Q isolated from E. coli methyl-deficient tRNA was determined to be 7-(aminomethyl)-7-deazaguanosine. The structure was deduced by means of its chromatographic and electrophoretic mobilities, and UV and mass spectra, in addition to comparison with the synthesized authentic compound. The same molecule is also found in tRNA of an E. coli mutant selected for deficient synthesis of modified nucleosides.
摘要
从大肠杆菌甲基缺乏型tRNA中分离出的修饰核苷Q的前体被确定为7-（氨甲基）-7-脱氮鸟苷。除了与合成的纯品化合物进行比较外，还通过其色谱和电泳迁移率、紫外光谱和质谱推断出了该结构。在一个因修饰核苷合成缺陷而被选择的大肠杆菌突变体的tRNA中也发现了相同的分子。
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