大肠杆菌突变体tRNA中存在的Q核苷前体的分离及其作为7-（氰基）-7-脱氮鸟苷的表征。
Isolation of Q nucleoside precursor present in tRNA of an E. coli mutant and its characterization as 7-(cyano)-7-deazaguanosine.
作者信息
Noguchi S, Yamaizumi Z, Ohgi T, Goto T, Nishimura Y, Hirota Y, Nishimura S
出版信息
Nucleic Acids Res. 1978 Nov;5(11):4215-23. doi: 10.1093/nar/5.11.4215.
Abstract
One of the E. coli mutants selected for deficiency of modified nucleoside Q was found to contain an analogue of Q and normal guanosine in place of Q. The analogue of Q, designated as preQo, was isolated on a large scale from purified tRNATyr containing preQo. The structure of preQo was determined to be 7-(cyano)-7-deazaguanosine by comparison of its ultraviolet absorption spectra, thin-layer chromatographic mobility and mass spectrum with those of synthetic material.
摘要
在筛选出的缺乏修饰核苷Q的大肠杆菌突变体中，有一个被发现含有Q的类似物以及取代Q的正常鸟苷。将这个Q的类似物命名为preQo，它是从含有preQo的纯化tRNATyr中大规模分离得到的。通过将其紫外吸收光谱、薄层色谱迁移率和质谱与合成材料的相应数据进行比较，确定preQo的结构为7-（氰基）-7-脱氮鸟苷。
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