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(可切除)胰腺癌新辅助和辅助治疗的未来概念

[Future concepts for neoadjuvant and adjuvant treatment of (resectable) pancreatic cancer].

作者信息

Seufferlein Thomas, Michalski Christoph

机构信息

Klinik für Innere Medizin I, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Deutschland.

Klinik für Allgemein- und Viszeralchirurgie, Universitätsklinikum Ulm, Ulm, Deutschland.

出版信息

Chirurg. 2022 May;93(5):441-445. doi: 10.1007/s00104-022-01623-w. Epub 2022 Apr 4.

DOI:10.1007/s00104-022-01623-w
PMID:35376964
Abstract

Pancreatic cancer still has a very unfavorable prognosis. This is true even for the comparably small group of patients (maximum 15%) who are diagnosed with a clearly resectable tumor. The article provides information on the current statements of the S3 guidelines on adjuvant and neoadjuvant treatment of resectable pancreatic cancer and describes adjuvant and neoadjuvant treatment strategies. Furthermore, the article pursues the questions of if and for whom a total neoadjuvant treatment is suitable and which options of a personalized treatment are available for resectable pancreatic cancer.

摘要

胰腺癌的预后仍然非常不理想。即使对于诊断为可明确切除肿瘤的相对较小的患者群体(最多15%)来说也是如此。本文提供了S3指南关于可切除胰腺癌辅助和新辅助治疗的当前声明信息,并描述了辅助和新辅助治疗策略。此外,本文探讨了全新辅助治疗是否适合以及适合哪些患者的问题,以及可切除胰腺癌有哪些个性化治疗选择。

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本文引用的文献

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A Prospective Feasibility Trial to Challenge Patient-Derived Pancreatic Cancer Organoids in Predicting Treatment Response.一项前瞻性可行性试验,旨在验证患者来源的胰腺癌类器官在预测治疗反应方面的效果。
Cancers (Basel). 2021 May 21;13(11):2539. doi: 10.3390/cancers13112539.
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Total neoadjuvant FOLFIRINOX versus neoadjuvant gemcitabine-based chemoradiotherapy and adjuvant gemcitabine for resectable and borderline resectable pancreatic cancer (PREOPANC-2 trial): study protocol for a nationwide multicenter randomized controlled trial.总新辅助 FOLFIRINOX 对比新辅助吉西他滨为基础的放化疗和辅助吉西他滨治疗可切除和交界可切除胰腺癌(PREOPANC-2 试验):一项全国多中心随机对照试验的研究方案。
BMC Cancer. 2021 Mar 23;21(1):300. doi: 10.1186/s12885-021-08031-z.
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Surgical Outcome Results From SWOG S1505: A Randomized Clinical Trial of mFOLFIRINOX Versus Gemcitabine/Nab-paclitaxel for Perioperative Treatment of Resectable Pancreatic Ductal Adenocarcinoma.SWOG S1505 研究的手术结果:吉西他滨/白蛋白紫杉醇对比改良 FOLFIRINOX 用于可切除胰腺导管腺癌围手术期治疗的随机临床试验。
Ann Surg. 2020 Sep 1;272(3):481-486. doi: 10.1097/SLA.0000000000004155.
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Preoperative Chemoradiotherapy Versus Immediate Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Results of the Dutch Randomized Phase III PREOPANC Trial.可切除及临界可切除胰腺癌的术前放化疗与直接手术对比:荷兰随机III期PREOPANC试验结果
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FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer.FOLFIRINOX 或吉西他滨作为胰腺癌的辅助治疗。
N Engl J Med. 2018 Dec 20;379(25):2395-2406. doi: 10.1056/NEJMoa1809775.
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International consensus on definition and criteria of borderline resectable pancreatic ductal adenocarcinoma 2017.2017 年国际胰腺导管腺癌边界可切除定义和标准的共识。
Pancreatology. 2018 Jan;18(1):2-11. doi: 10.1016/j.pan.2017.11.011. Epub 2017 Nov 22.
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Pancreatic Adenocarcinoma, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.《胰腺导管腺癌临床实践指南(2017 年第 2 版)》,NCCN 肿瘤学临床实践指南。
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Lancet. 2017 Mar 11;389(10073):1011-1024. doi: 10.1016/S0140-6736(16)32409-6. Epub 2017 Jan 25.
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