人类Ki-ras癌基因编码两种具有转化活性的p21蛋白。
A human Ki-ras oncogene encodes two transforming p21 proteins.
作者信息
McCoy M S, Weinberg R A
出版信息
Mol Cell Biol. 1986 Apr;6(4):1326-8. doi: 10.1128/mcb.6.4.1326-1328.1986.
Abstract
The human Ki-ras gene was previously reported to contain two alternative fourth exons which encode two distinct p21 proteins differing only at their carboxy termini. The present study shows that either p21 protein is able on its own to transform NIH 3T3 cells to a tumorigenic state.
摘要
人类Ki-ras基因先前报道含有两个选择性的第四外显子，它们编码两种仅在羧基末端不同的独特p21蛋白。本研究表明，任一p21蛋白自身都能够将NIH 3T3细胞转化为致瘤状态。
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