Department of Neurology and Neurosurgery, Brain Center, UMC Utrecht, Utrecht, Netherlands.
Radiology department, Center for Image Sciences, UMC Utrecht, Utrecht, Netherlands.
PLoS Comput Biol. 2022 Apr 4;18(4):e1009955. doi: 10.1371/journal.pcbi.1009955. eCollection 2022 Apr.
For cortical motor activity, the relationships between different body part representations is unknown. Through reciprocal body part relationships, functionality of cortical motor areas with respect to whole body motor control can be characterized. In the current study, we investigate the relationship between body part representations within individual neuronal populations in motor cortices, following a 7 Tesla fMRI 18-body-part motor experiment in combination with our newly developed non-rigid population Response Field (pRF) model and graph theory. The non-rigid pRF metrics reveal somatotopic structures in all included motor cortices covering frontal, parietal, medial and insular cortices and that neuronal populations in primary sensorimotor cortex respond to fewer body parts than secondary motor cortices. Reciprocal body part relationships are estimated in terms of uniqueness, clique-formation, and influence. We report unique response profiles for the knee, a clique of body parts surrounding the ring finger, and a central role for the shoulder and wrist. These results reveal associations among body parts from the perspective of the central nervous system, while being in agreement with intuitive notions of body part usage.
对于皮质运动活动，不同身体部位表示之间的关系尚不清楚。通过相互的身体部位关系，可以描述皮质运动区域与整个身体运动控制的功能关系。在当前的研究中，我们结合新开发的非刚性群体响应场（pRF）模型和图论，研究了单个运动皮质神经元群体中身体部位表示之间的关系，该研究是在 7T 磁共振 fMRI 18 个身体部位运动实验之后进行的。非刚性 pRF 指标揭示了包括额、顶、内和岛叶皮质在内的所有运动皮质中的躯体感觉结构，并且初级感觉运动皮质中的神经元群体对身体部位的反应少于次级运动皮质。以独特性、团块形成和影响来估计相互的身体部位关系。我们报告了膝盖、围绕无名指的身体部位群的独特反应谱，以及肩部和腕部的核心作用。这些结果从中枢神经系统的角度揭示了身体部位之间的关联，同时与身体部位使用的直观概念相一致。
