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自组装聚合物纳米胶束用于皮肤癌和光毒性的未来治疗:治疗和临床进展。

Self-Assembly Polymeric Nano Micelles for the Futuristic Treatment of Skin Cancer and Phototoxicity: Therapeutic and Clinical Advancement.

机构信息

MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India.

Department of Pharmacy, School of Medical and Allied Sciences, G D Goenka University, Sohna Road, Gurugram-122103, Haryana, India.

出版信息

Crit Rev Ther Drug Carrier Syst. 2022;39(2):79-95. doi: 10.1615/CritRevTherDrugCarrierSyst.2021035589.

Abstract

In the last few years, the polymeric micelles played a major role as a drug carrier in nano-sized drug delivery system. The polymeric micelles are designed from synthetic block co-polymers and graft copolymers. In the mixed micelles, the bilayer lipid membrane and surfactants are used. Both micelles are in nano-sized and used to enhance the drug delivery to treat different diseases. In this review, we will discuss some examples from the literature included demonstrating the polymeric micelles used as drug-carriers in skin cancer treatment by using different drugs. We also summarized mixed micelles, polymeric micelles in skin drug delivery, various polymers, and techniques of polymeric micelles. These micelles may improve delivery of drug in the skin's targeted sites in specific and dermatological diseases like skin cancer, acne, and fungal infection. In the comparison of surfactant micelles, the polymeric micelles are more stable. Polymeric micelles act as a colloidal carrier for incorporating poorly water-soluble and amphiphilic drugs.

摘要

在过去的几年中,聚合物胶束作为纳米药物递送系统中的药物载体发挥了重要作用。聚合物胶束是由合成嵌段共聚物和接枝共聚物设计而成。混合胶束中使用双层脂质膜和表面活性剂。胶束均为纳米级,用于增强药物递送以治疗不同疾病。在这篇综述中,我们将讨论文献中的一些例子,这些例子展示了聚合物胶束作为药物载体在皮肤癌治疗中使用不同药物的情况。我们还总结了混合胶束、聚合物胶束在皮肤药物输送中的应用、各种聚合物以及聚合物胶束的技术。这些胶束可以改善药物在皮肤靶向部位的递送,特别是在特定的皮肤疾病如皮肤癌、痤疮和真菌感染中。与表面活性剂胶束相比,聚合物胶束更稳定。聚合物胶束作为一种胶体载体,可用于包埋水溶性差和两亲性药物。

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