Al-Rawas Omar A, Baddar Sawasn, Al-Maniri Abdullah A, Balaji Jothi, Jayakrishnan B, Al-Riyami Bazdawi M
Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
Lung. 2009 Aug;187(4):245-51. doi: 10.1007/s00408-009-9148-4. Epub 2009 Apr 28.
International guidelines recommend the use of population-specific reference values to eliminate the well-recognized influence of ethnic variation on lung function. This study was designed to derive spirometric prediction equations for healthy Omani adults. Forced vital capacity (FVC), forced expiratory volume in one second (FEV(1)), peak expiratory flow rate (PEFR), and forced expiratory flow at 25% to 75% of FVC (FEF(25-75%)) were measured in 419 "healthy" nonsmoking Omani adults (256 men, 163 women), aged 18-65 years. Multiple linear regression analysis was performed for each spirometric parameter against age, height, and weight for men and women separately, and prediction equations for all the above parameters were derived and compared with values derived using equations published from other populations. All measured spirometric parameters increased with height and decreased with age, and they were all significantly higher in men. In contrast, FEV(1)/FVC% values decreased with height and increased with age and were higher in women. The predicted normal values of FVC and FEV(1) for our subjects using the derived equations were lower by 7-17% compared with respective Caucasian values, with smaller difference in the predicted values of PEFR, FEV(1)/FVC%, and FEF(25-75%). This report presents previously unavailable spirometric reference equations for the Omani adults. Our findings highlight the need to use reference values based on updated data derived from relevant populations.
国际指南建议使用针对特定人群的参考值，以消除种族差异对肺功能的公认影响。本研究旨在推导健康阿曼成年人的肺量计预测方程。对419名年龄在18至65岁之间的“健康”不吸烟阿曼成年人（256名男性，163名女性）测量了用力肺活量（FVC）、一秒用力呼气容积（FEV₁）、呼气峰值流速（PEFR）以及FVC的25%至75%时的用力呼气流量（FEF₂₅₋₇₅%）。分别针对男性和女性，对每个肺量计参数与年龄、身高和体重进行多元线性回归分析，推导了上述所有参数的预测方程，并与使用其他人群公布的方程得出的值进行比较。所有测量的肺量计参数均随身高增加而增加，随年龄增长而降低，且男性的所有参数均显著更高。相比之下，FEV₁/FVC%值随身高降低，随年龄增加，且女性更高。使用推导方程得出的我们研究对象的FVC和FEV₁预测正常值比相应的白种人值低7%至17%，PEFR、FEV₁/FVC%和FEF₂₅₋₇₅%的预测值差异较小。本报告提供了此前未有的阿曼成年人肺量计参考方程。我们的研究结果强调了使用基于来自相关人群的最新数据的参考值的必要性。
