维生素 D 状态和 VDR 多态性作为分化型甲状腺癌的预后因素。
Vitamin D Status and VDR Polymorphisms as Prognostic Factors in Differentiated Thyroid Carcinoma.
机构信息
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;
Research Laboratory, "C. I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
出版信息
In Vivo. 2022 Sep-Oct;36(5):2434-2441. doi: 10.21873/invivo.12977.
BACKGROUND/AIM: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms are involved in a variety of biological processes including cell proliferation, apoptosis, and adhesion in malignant tumors. This study investigated whether vitamin D levels and genetic variations of VDR are risk factors for thyroid cancer.
PATIENTS AND METHODS
Patients who underwent surgery for differentiated thyroid carcinoma (n=113) and those with benign thyroid pathology (n=150) were genotyped for VDR gene polymorphisms (ApaI, TaqI, FokI, and BsmI) and their 25(OH)D levels were simultaneously measured. Demographic data and histopathologic reports were also acquired for all patients.
RESULTS
Vitamin D levels were significantly lower in the thyroid cancer group (p=0.03). FokI and TaqI polymorphisms were more frequent in the thyroid cancer patients (p<0.001). Compared to control, the proportion of the FokI Ff genotype was increased (p<0.0006) and the proportion of the TaqI Tt genotype was also higher among patients with thyroid cancer (p<0.0001). The Ff genotype of FokI was also associated with multifocality, invasive pattern, and risk for local metastasis.
CONCLUSION
The VDR gene polymorphism FokI may be associated with the risk of thyroid cancer and its more aggressive forms.
背景/目的：维生素 D 缺乏和维生素 D 受体（VDR）基因多态性参与多种生物学过程，包括恶性肿瘤中的细胞增殖、凋亡和黏附。本研究探讨了维生素 D 水平和 VDR 基因多态性是否是甲状腺癌的危险因素。
患者和方法
对接受分化型甲状腺癌手术的患者（n=113）和患有良性甲状腺病变的患者（n=150）进行 VDR 基因多态性（ApaI、TaqI、FokI 和 BsmI）的基因分型，并同时测量其 25（OH）D 水平。还为所有患者获取了人口统计学数据和组织病理学报告。
结果
甲状腺癌组的维生素 D 水平显著降低（p=0.03）。FokI 和 TaqI 多态性在甲状腺癌患者中更为常见（p<0.001）。与对照组相比，FokI Ff 基因型的比例增加（p<0.0006），甲状腺癌患者中 TaqI Tt 基因型的比例也更高（p<0.0001）。FokI 的 Ff 基因型也与多灶性、侵袭性模式和局部转移风险相关。
结论
VDR 基因多态性 FokI 可能与甲状腺癌及其侵袭性更强的形式的风险相关。
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