Département Anesthésie Réanimation, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France.
Université de Lyon, UJM, Inter-university Laboratory of Human Movement Biology, EA 7424, 42023, Saint-Etienne, France.
Sci Rep. 2022 Apr 4;12(1):5631. doi: 10.1038/s41598-022-09623-w.
Prolonged stays in intensive care units (ICU) are responsible for long-lasting consequences, fatigue being one of the more debilitating. Yet, fatigue prevalence for patients that have experienced ICU stays remains poorly investigated. This study aimed to evaluate fatigue prevalence and the level of physical activity in ICU survivors from 6 months to 5 years after ICU discharge using the Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) and Godin questionnaires, respectively. Data from 351 ICU survivors (out of 1583 contacted) showed that 199 (57%) and 152 (43%) were considered as fatigued and non-fatigued, respectively. The median FACIT-F scores for fatigued versus non-fatigued ICU survivors were 21 (14-27) and 45 (41-48), respectively (p < 0.001). Time from discharge had no significant effect on fatigue prevalence (p = 0.30) and fatigued ICU survivors are less active (p < 0.001). In multivariate analysis, the only risk factor of being fatigued that was identified was being female. We reported a high prevalence of fatigue among ICU survivors. Sex was the only independent risk factor of being fatigued, with females being more prone to this symptom. Further studies should consider experimental approaches that help us understand the objective causes of fatigue, and to build targeted fatigue management interventions.
长时间入住重症监护病房（ICU）会导致长期的后果，疲劳是其中一种较为衰弱的后果。然而，经历过 ICU 住院的患者的疲劳患病率仍未得到充分研究。本研究旨在使用慢性病治疗疲劳功能评估（FACIT-F）和 Godin 问卷，分别评估 ICU 幸存者在 ICU 出院后 6 个月至 5 年内的疲劳患病率和身体活动水平。来自 351 名 ICU 幸存者（从 1583 名联系到的患者中）的数据显示，199 名（57%）和 152 名（43%）患者分别被认为是疲劳和非疲劳患者。疲劳和非疲劳 ICU 幸存者的 FACIT-F 评分中位数分别为 21（14-27）和 45（41-48）（p<0.001）。从出院到疲劳患病率无显著影响（p=0.30），且疲劳 ICU 幸存者的活动量较少（p<0.001）。在多变量分析中，唯一确定的疲劳风险因素是女性。我们报告了 ICU 幸存者中疲劳的高患病率。性别是疲劳的唯一独立危险因素，女性更容易出现这种症状。进一步的研究应考虑实验方法，帮助我们了解疲劳的客观原因，并构建有针对性的疲劳管理干预措施。
