Spadaro Savino, Capuzzo Maurizia, Valpiani Giorgia, Bertacchini Sara, Ragazzi Riccardo, Dalla Corte Francesca, Terranova Simona, Marangoni Elisabetta, Volta Carlo Alberto
Department of Morphology, Experimental Medicine and Surgery, Section of Anaesthesia and Intensive Care, University of Ferrara, Azienda Ospedaliero-Universitaria S. Anna, Via Aldo Moro, 8. 44121, Cona, Ferrara, Italy.
Research and Innovation Office, Azienda Ospedaliero-Universitaria S. Anna, Cona, Ferrara, Italy.
Health Qual Life Outcomes. 2016 Oct 18;14(1):148. doi: 10.1186/s12955-016-0554-z.
Fatigue has not been investigated in long-term Intensive Care Unit (ICU) survivors. This study aimed to assess fatigue through a specific instrument, namely the Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) scale, in ICU survivors one year after hospital discharge. A secondary aim was to compare the findings of FACIT-F with those of the Vitality domain (VT) of the 36-item Short-Form Health Survey (SF-36).
This prospective cohort study was performed on 56 adult patients with a Length Of Stay (LOS) in ICU longer than 72 h. At one year after hospital discharge, FACIT-F and SF-36 questionnaires were administered to consenting patients by direct interview. FACIT-F was measured as raw (range 0-52), and FACIT-F-trans value (range 0-100). Past medical history, and demographic and clinical ICU-related variables were collected.
The patients' median age was 67.5, Simplified Acute Physiology Score II 31, and LOS in ICU 5 days. The median raw FACIT-F of the patients was 41, and Cronbach's α was 0.937. The correlation coefficient between FACIT-F-trans and VT of SF-36 was 0.660 (p < 0.001). Both FACIT-F and VT were related to dyspnoea scale (p = 0.01). A Bland-Altman plot of VT vs FACIT-F-trans showed a bias of -0.8 with 95 % limits of agreement from 35.7 to -34.1. The linear regression between differences and means was 0.639, suggesting a significant proportional bias.
The 13-item FACIT-F questionnaire is valid to assess fatigue of long-term ICU survivors. VT of SF-36 relates to FACIT-F, but consists of only four items assessing two positive and two negative aspects. FACIT-F grasps the negative aspects of fatigue better than VT. Specific tools assess specific conditions better that general tools.
ClinicalTrials.gov: NCT02684877 .
尚未对长期重症监护病房（ICU）幸存者的疲劳情况进行研究。本研究旨在通过一种特定工具，即慢性病治疗功能评估疲劳（FACIT-F）量表，对出院一年后的ICU幸存者的疲劳情况进行评估。次要目的是将FACIT-F的结果与36项简明健康调查（SF-36）活力领域（VT）的结果进行比较。
本前瞻性队列研究对56名在ICU住院时间超过72小时的成年患者进行。出院一年后，通过直接访谈对同意参与的患者发放FACIT-F和SF-36问卷。FACIT-F以原始分（范围0 - 52）和FACIT-F转换分（范围0 - 100）进行测量。收集患者既往病史以及人口统计学和临床ICU相关变量。
患者的中位年龄为67.5岁，急性生理与慢性健康状况评分系统II为31分，在ICU的住院时间为5天。患者FACIT-F原始分的中位数为41分，Cronbach's α为0.937。FACIT-F转换分与SF-36的VT之间的相关系数为0.660（p < 0.001）。FACIT-F和VT均与呼吸困难量表相关（p = 0.01）。VT与FACIT-F转换分的Bland-Altman图显示偏差为 -0.8，95%一致性界限为35.7至 -34.1。差异与均值之间的线性回归为0.639，表明存在显著的比例偏差。
13项FACIT-F问卷可有效评估长期ICU幸存者的疲劳情况。SF-36的VT与FACIT-F相关，但仅由四项评估两个积极方面和两个消极方面的内容组成。FACIT-F比VT能更好地把握疲劳的消极方面。特定工具比通用工具能更好地评估特定情况。
ClinicalTrials.gov：NCT02684877 。
