中脑视前区 GABA 和谷氨酸能神经元对睡眠行为发挥不同的控制作用。
Median preoptic GABA and glutamate neurons exert differential control over sleep behavior.
机构信息
Department of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Department of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA; Department of Zoology and Physiology, Program in Neuroscience, University of Wyoming, Laramie, WY 82071, USA.
出版信息
Curr Biol. 2022 May 9;32(9):2011-2021.e3. doi: 10.1016/j.cub.2022.03.039. Epub 2022 Apr 5.
Previous studies suggest that the median preoptic nucleus (MnPO) of the hypothalamus plays an important role in regulating the wake-sleep cycle and, in particular, homeostatic sleep drive. However, the precise cellular phenotypes, targets, and central mechanisms by which the MnPO neurons regulate the wake-sleep cycle remain unknown. Both excitatory and inhibitory MnPO neurons innervate brain regions implicated in sleep promotion and maintenance, suggesting that both cell types may participate in sleep control. Using genetically targeted approaches, we investigated the role of the MnPO GABAergic (MnPO) and glutamatergic (MnPO) neurons in modulating wake-sleep behavior of mice. We found that both neuron populations differentially participate in wake-sleep control, with MnPO neurons being involved in sleep homeostasis and MnPO neurons facilitating sleep during allostatic (stressful) challenges.
先前的研究表明，下丘脑的视前正中核（MnPO）在调节觉醒-睡眠周期方面起着重要作用，特别是在稳态睡眠驱动方面。然而，MnPO 神经元调节觉醒-睡眠周期的确切细胞表型、靶点和中枢机制仍不清楚。兴奋和抑制性 MnPO 神经元支配与促进和维持睡眠有关的脑区，这表明这两种细胞类型都可能参与睡眠控制。使用基因靶向方法，我们研究了 MnPO 神经元（MnPO）和谷氨酸能神经元（MnPO）在调节小鼠觉醒-睡眠行为中的作用。我们发现，这两种神经元群体在觉醒-睡眠控制中表现出不同的参与，MnPO 神经元参与睡眠稳态，而 MnPO 神经元则在全身适应（应激）挑战期间促进睡眠。
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