Akaza H, Koseki K, Niijima T
Urol Res. 1986;14(4):223-5. doi: 10.1007/BF00441118.
The early histological changes in bladder urothelium following transurethral cauterization were sequentially studied in female rats, mice, hamsters and guinea pigs. The changes differed markedly between species: papillary hyperplasia or papilloma in the rats and simple hyperplasia in the mice, hamsters and guinea pigs. The regenerative response to the fulgurative ulcer within a given species was similar to the early response previously observed by others following administration of known bladder carcinogens. This suggests that there may be a regulatory mechanism in the urothelium which is common to urothelial proliferations induced by both carcinogenic and non-carcinogenic stimulations, though differing between animal species.
对雌性大鼠、小鼠、仓鼠和豚鼠经尿道烧灼后膀胱尿路上皮的早期组织学变化进行了序贯研究。不同物种之间的变化差异显著：大鼠出现乳头状增生或乳头状瘤，而小鼠、仓鼠和豚鼠则出现单纯性增生。给定物种内对电灼溃疡的再生反应类似于其他人先前观察到的在给予已知膀胱致癌物后早期反应。这表明尿路上皮中可能存在一种调节机制，它对于致癌和非致癌刺激诱导的尿路上皮增殖是共同的，尽管在动物物种之间存在差异。
