Swedberg K
Acta Pharmacol Toxicol (Copenh). 1986;59 Suppl 6:49-51. doi: 10.1111/j.1600-0773.1986.tb02546.x.
In several studies the nitrate effects on central hemodynamics during less than 24 hours have been evaluated in heart failure. Higher doses than in angina have been used. A pronounced response is seen acutely. An attenuation has been reported after 12-24 hours. A relation to continuous (intravenous, transdermal) administration of nitroglycerin has been proposed, but it is not clear. During chronic treatment with ISDN a tolerance is not obvious within 12 weeks. The heart failure patient has a different neurohumoral situation compared to angina patients. This could be one reason for differences in tolerance development during nitrate therapy.
在多项研究中，已对心力衰竭患者在不到24小时内硝酸盐对中心血流动力学的影响进行了评估。使用的剂量高于心绞痛患者。急性时可见明显反应。据报道，12 - 24小时后反应减弱。有人提出这与硝酸甘油的持续（静脉、经皮）给药有关，但尚不清楚。在使用异山梨醇二硝酸酯进行慢性治疗期间，12周内耐受性不明显。与心绞痛患者相比，心力衰竭患者的神经体液状况不同。这可能是硝酸盐治疗期间耐受性发展存在差异的原因之一。
