Project Group Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, Berlin, Germany.
Department of Ecology and Emergence of Zoonotic Diseases, Helmholtz Institute for One Health, Greifswald, Germany.
Influenza Other Respir Viruses. 2022 Sep;16(5):858-861. doi: 10.1111/irv.12984. Epub 2022 Apr 6.
Human respiratory pathogens have repeatedly caused lethal outbreaks in wild great apes across Africa, leading to population declines. Nonetheless, our knowledge of potential genomic changes associated with pathogen introduction and spread at the human-great ape interface remains sparse. Here, we made use of target enrichment coupled with next generation sequencing to non-invasively investigate five outbreaks of human-introduced respiratory disease in wild chimpanzees living in Taï National Park, Ivory Coast. By retrieving 34 complete viral genomes and three distinct constellations of pneumococcal virulence factors, we provide genomic insights into these spillover events and describe a framework for non-invasive genomic surveillance in wildlife.
人类呼吸道病原体多次在非洲野生大猿中引发致命疫情，导致大猿数量下降。尽管如此，我们对于在人类与大猿交界区域由病原体传入和传播所导致的潜在基因组变化的认识仍然有限。在这里，我们利用靶向富集与下一代测序技术，对生活在象牙海岸泰莱国家公园的野生黑猩猩中五次由人类引入的呼吸道疾病爆发进行了非侵入性研究。通过获得 34 个完整的病毒基因组和三种不同的肺炎球菌毒力因子组合，我们提供了对这些溢出事件的基因组见解，并描述了野生动物非侵入性基因组监测的框架。
