一种针对5,6 - 二氢前列环素（PGI1）的抗血清，它也能结合前列环素。

An antiserum to 5,6-dihydro prostacyclin (PGI1) which also binds prostacyclin.

作者信息

Bunting S, Moncada S, Reed P, Salmon J A, Vane J R

出版信息

Prostaglandins. 1978 Apr;15(4):565-73. doi: 10.1016/0090-6980(78)90053-9.

Abstract

An antiserum was raised in rabbits using 5,6-dihydro prostacyclin, a stable analogue of prostacyclin, as the hapten, conjugated to bovine serum albumin. When added to platelet rich plasma the antiserum neutralised the inhibitory activity of prostacyclin, prostaglandin E1 and D2. The amount of antiserum required to neutralise completely a dose of prostacyclin giving 90-95% inhibition of ADP induced aggregation was 10-30 times less than that required for the other two prostaglandins. Small amounts of antiserum prevented the inhibitory activity of prostacyclin generated from endothelial cells in platelet rich plasma.

摘要

以前列腺素I2（前列环素）的稳定类似物5,6 - 二氢前列环素作为半抗原与牛血清白蛋白偶联，在兔体内制备抗血清。当将该抗血清添加到富含血小板的血浆中时，它可中和前列环素、前列腺素E1和D2的抑制活性。完全中和能使ADP诱导的聚集受到90 - 95%抑制的一定剂量前列环素所需的抗血清量，比中和其他两种前列腺素所需的抗血清量少10 - 30倍。少量抗血清可阻止富含血小板血浆中内皮细胞产生的前列环素的抑制活性。