Cardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, Omaha, NE, USA.
Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE, USA.
Pharmacol Ther. 2022 Oct;238:108182. doi: 10.1016/j.pharmthera.2022.108182. Epub 2022 Apr 4.
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a transmembrane protein expressed on endothelial cells, white blood cells, smooth muscle cells and platelets. TREM-1 plays an important role in innate immunity. TREM-1 activation pathways are implicated both in sepsis and in non-infectious inflammatory conditions, including atherosclerosis. TREM-1 enhances the subendothelial lipid accumulation and expression of pro-inflammatory cytokines and matrix-degrading enzymes, thereby promoting inflammation and plaque destabilization. TREM-1 inhibitors attenuate the inflammatory process in the atherosclerotic plaque, leading to plaque stabilization. This review focuses on the role of TREM-1 in the pathophysiology of atherosclerosis and the effects of TREM-1 inhibition in the natural history of the disease.
髓系细胞触发受体-1（TREM-1）是一种表达在血管内皮细胞、白细胞、平滑肌细胞和血小板上的跨膜蛋白。TREM-1 在先天免疫中发挥重要作用。TREM-1 的激活途径既与脓毒症有关，也与非传染性炎症性疾病有关，包括动脉粥样硬化。TREM-1 增强了亚内皮脂质积聚以及促炎细胞因子和基质降解酶的表达，从而促进炎症和斑块不稳定。TREM-1 抑制剂可减轻动脉粥样硬化斑块中的炎症过程，从而稳定斑块。本文重点介绍了 TREM-1 在动脉粥样硬化发病机制中的作用以及 TREM-1 抑制在疾病自然史中的作用。
