Bratisl Lek Listy. 2021;122(2):116-119. doi: 10.4149/BLL_2021_017.
Frailty is a common problem in patients with type 2 diabetes mellitus (T2DM). It is considered to be associated with inflammation. Novel markers derived from hemogram, such as neutrophil/lymphocyte ratio (NLR) and mean platelet volume/lymphocyte ratio (MPVLR), are proposed as inflammatory markers. In present study, we aimed to compare NLR and MPVLR levels of frail patients with T2DM to non‑frail diabetic subjects.
Diabetic subjects were grouped in frail and non-frail groups according to the Edmonton Frail Scale. General characteristics and laboratory data of the frail and non-frail groups were compared.
The MPVLR of the frail (3.9 [1.4-13.2] %) group was significantly higher than that of the non-frail (3.4 [1.5-6.9] %) group (p = 0.02). MPVLR was positively and significantly correlated with Edmonton Frail Scale score (r = 0.21, p = 0.03). A MPVLR level greater than 3.41 % has 71 % sensitivity and 51 % specifity in predicting frailty.
We suggest that elevated MPVLR could be a finding that marks frailty in diabetic subjects. Inexpensive and easy‑to‑assess nature of the MPVLR may be useful in predicting frailty in type 2 diabetic population (Tab. 2, Fig. 1, Ref. 32).
衰弱是 2 型糖尿病（T2DM）患者常见的问题。它被认为与炎症有关。源自血常规的新型标志物，如中性粒细胞/淋巴细胞比值（NLR）和平均血小板体积/淋巴细胞比值（MPVLR），被提议作为炎症标志物。在本研究中，我们旨在比较虚弱的 T2DM 患者和非虚弱的糖尿病患者的 NLR 和 MPVLR 水平。
根据埃德蒙顿虚弱量表将糖尿病患者分为虚弱组和非虚弱组。比较虚弱组和非虚弱组的一般特征和实验室数据。
虚弱组（3.9 [1.4-13.2]%）的 MPVLR 明显高于非虚弱组（3.4 [1.5-6.9]%）（p=0.02）。MPVLR 与埃德蒙顿虚弱量表评分呈正相关（r=0.21，p=0.03）。MPVLR 水平大于 3.41%时，对衰弱的预测具有 71%的敏感性和 51%的特异性。
我们认为，升高的 MPVLR 可能是糖尿病患者衰弱的标志。MPVLR 价格低廉且易于评估，可能有助于预测 2 型糖尿病患者的衰弱（表 2，图 1，参考文献 32）。
