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Omicron: Master of immune evasion maintains robust ACE2 binding.

作者信息

Hoffmann Markus, Zhang Lu, Pöhlmann Stefan

机构信息

Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.

Georg-August-University Göttingen, Göttingen, Germany.

出版信息

Signal Transduct Target Ther. 2022 Apr 7;7(1):118. doi: 10.1038/s41392-022-00965-5.

DOI:10.1038/s41392-022-00965-5
PMID:35393393
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8988531/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c36c/8989873/7395202a8f79/41392_2022_965_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c36c/8989873/7395202a8f79/41392_2022_965_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c36c/8989873/7395202a8f79/41392_2022_965_Fig1_HTML.jpg

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Cell Rep. 2022 Apr 26;39(4):110729. doi: 10.1016/j.celrep.2022.110729. Epub 2022 Apr 11.
2
Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement.SARS-CoV-2 奥密克戎免疫逃逸和受体结合的结构基础。
Science. 2022 Feb 25;375(6583):864-868. doi: 10.1126/science.abn8652. Epub 2022 Jan 25.
3
SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex.
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ACS Nanosci Au. 2024 Mar 8;4(2):136-145. doi: 10.1021/acsnanoscienceau.3c00060. eCollection 2024 Apr 17.
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Soluble Angiotensin-Converting Enzyme 2 Protein Improves Survival and Lowers Viral Titers in Lethal Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection with the Delta Variant.可溶性血管紧张素转换酶 2 蛋白可改善德尔塔变异株引起的严重急性呼吸综合征冠状病毒 2 型感染致死性小鼠模型的存活率并降低病毒滴度。
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