School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Great Lakes Genomics Center, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Nat Nanotechnol. 2022 Jun;17(6):661-669. doi: 10.1038/s41565-022-01096-2. Epub 2022 Apr 7.
Physico-chemical characteristics of engineered nanomaterials are known to be important in determining the impact on organisms but effects are equally dependent upon the characteristics of the organism exposed. Species sensitivity may vary by orders of magnitude, which could be due to differences in the type or magnitude of the biochemical response, exposure or uptake of nanomaterials. Synthesizing conclusions across studies and species is difficult as multiple species are not often included in a study, and differences in batches of nanomaterials, the exposure duration and media across experiments confound comparisons. Here three model species, Danio rerio, Daphnia magna and Chironomus riparius, that differ in sensitivity to lithium cobalt oxide nanosheets are found to differ in immune-response, iron-sulfur protein and central nervous system pathways, among others. Nanomaterial uptake and dissolution does not fully explain cross-species differences. This comparison provides insight into how biomolecular responses across species relate to the varying sensitivity to nanomaterials.
工程纳米材料的物理化学特性被认为是决定其对生物体影响的重要因素，但影响同样取决于暴露的生物体的特性。物种敏感性可能相差几个数量级，这可能是由于生物化学反应的类型或幅度、纳米材料的暴露或摄取的差异。由于研究中通常不包括多种物种，并且纳米材料批次、暴露持续时间和实验介质存在差异，因此很难综合不同研究和物种的结论。在这里，三种模式物种，即斑马鱼、大型蚤和摇蚊，对钴酸锂纳米片的敏感性不同，它们在免疫反应、铁硫蛋白和中枢神经系统途径等方面存在差异。纳米材料的摄取和溶解并不能完全解释跨物种差异。这种比较提供了关于物种间生物分子反应与对纳米材料的不同敏感性之间关系的深入了解。
