Zhu Xiaoxuan, Yang Kai, Xiao Yunfan, Ye Cong, Zheng Jingwei, Su Binbin, Zheng Yang, Zhang Xinyao, Shi Keai, Li Chunmei, Lu Fan, Qu Jia, Li Ming, Cui Lele
Eye Hospital and School of Ophthalmology and Optometry, National Clinical Research Center for Ocular Diseases, Wenzhou Medical University, Wenzhou, China.
Acta Ophthalmol. 2022 Nov;100(7):e1479-e1488. doi: 10.1111/aos.15157. Epub 2022 Apr 9.
To investigate the association between cigarette smoking and retinal capillary plexus (RCP) using optical coherence tomography angiography (OCTA) and to examine whether potential vascular risk factors could impact their association.
This is a cross-sectional, community-based study. The Jidong Eye Cohort Study included participants aged ≥18 years in the Jidong community (Tangshan city, northern China) from August 2019 to January 2020. All participants underwent comprehensive ophthalmic examination and completed detailed smoking questionnaires. Retinal vessel density in the superficial and deep RCP was automatically measured using OCTA.
Of the 2598 participants included in the study, 2026 (78.0%) never smoked and 572 (22.0%) had a history of smoking (494 [19.0%] current smokers and 78 [3.0%] former smokers). The median (interquartile range) age was 41 (34-52) years for the non-smoking group and 45 (35-54.5) years for the smoking group. Multivariable analysis showed that smoking history is associated with a low deep RCP vessel density in the parafovea (β, -0.53; 95% confidence interval [CI], -0.82 to -0.24) and four quadrants. Increased smoking pack-years were associated with reduced deep RCP vessel density in the parafovea (p for trend <0.001) and four quadrants. The significant interaction between diabetes and smoking only was found for superficial RCP vessel density in the parafovea (p for interaction = 0.014) and four quadrants except for the temporal quadrants.
Cigarette smoking is an independent risk factor for reduced deep RCP vessel density. Our findings imply the potential detrimental effect of smoking on the occurrence of ocular diseases.
使用光学相干断层扫描血管造影（OCTA）研究吸烟与视网膜毛细血管丛（RCP）之间的关联，并检查潜在的血管危险因素是否会影响它们之间的关联。
这是一项基于社区的横断面研究。冀东眼队列研究纳入了2019年8月至2020年1月期间来自中国北方唐山市冀东社区的年龄≥18岁的参与者。所有参与者均接受了全面的眼科检查并完成了详细的吸烟问卷。使用OCTA自动测量浅层和深层RCP中的视网膜血管密度。
在纳入研究的2598名参与者中，2026名（78.0%）从不吸烟，572名（22.0%）有吸烟史（494名[19.0%]为当前吸烟者，78名[3.0%]为既往吸烟者）。非吸烟组的年龄中位数（四分位间距）为41（34 - 52）岁，吸烟组为45（35 - 54.5）岁。多变量分析显示，吸烟史与黄斑旁中心凹深层RCP血管密度降低相关（β，-0.53；95%置信区间[CI]，-0.82至-0.24），且与四个象限相关。吸烟包年数增加与黄斑旁中心凹深层RCP血管密度降低相关（趋势p<0.001），且与四个象限相关。仅在黄斑旁中心凹浅层RCP血管密度方面发现糖尿病与吸烟之间存在显著交互作用（交互作用p = 0.014），且除颞侧象限外的四个象限也存在交互作用。
吸烟是深层RCP血管密度降低的独立危险因素。我们的研究结果表明吸烟对眼部疾病发生可能具有有害影响。
