School of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Centre for Human Brain Health, University of Birmingham, Birmingham, UK.
Int J Obes (Lond). 2022 Jul;46(7):1319-1327. doi: 10.1038/s41366-022-01115-1. Epub 2022 Apr 9.
BACKGROUND/OBJECTIVES: Intranasal (IN) administration of insulin decreases appetite in humans, but the underlying mechanisms are unclear, and it is unknown whether IN insulin affects the food intake of women with obesity.
SUBJECTS/METHODS: In a double-blind, placebo-controlled, crossover design, participants (35 lean women and 17 women with obesity) were randomized to receive 160 IU/1.6 mL of IN insulin or placebo in a counterbalanced order in the post prandial state. The effects of IN insulin on cookie intake, appetite, mood, food reward, cognition and neural activity were assessed.
IN insulin in the post prandial state reduced cookie intake, appetite and food reward relative to placebo and these effects were more pronounced for women with obesity compared with lean women. IN insulin also improved mood in women with obesity. In both BMI groups, IN insulin increased neural activity in the insula when viewing food pictures. IN insulin did not affect cognitive function.
These results suggest that IN insulin decreases palatable food intake when satiated by reducing food reward and that women with obesity may be more sensitive to this effect than lean women. Further investigation of the therapeutic potential of IN insulin for weight management in women with obesity is warranted.
背景/目的：经鼻给予胰岛素可降低人体食欲，但相关机制尚不清楚，也不知道经鼻给予胰岛素是否会影响肥胖女性的食物摄入量。
受试者/方法：采用双盲、安慰剂对照、交叉设计，将参与者（35 名瘦女性和 17 名肥胖女性）随机分为两组，在餐后状态下以交替方式接受 160IU/1.6mL 的经鼻胰岛素或安慰剂治疗。评估经鼻胰岛素对曲奇摄入量、食欲、情绪、食物奖赏、认知和神经活动的影响。
与安慰剂相比，经鼻胰岛素在餐后状态下减少了曲奇摄入量、食欲和食物奖赏，而肥胖女性的这些效果比瘦女性更为明显。经鼻胰岛素还改善了肥胖女性的情绪。在 BMI 两组中，经鼻胰岛素在观看食物图片时增加了脑岛的神经活动。经鼻胰岛素对认知功能没有影响。
这些结果表明，经鼻给予胰岛素在饱腹感状态下通过降低食物奖赏来减少美味食物的摄入，而肥胖女性可能比瘦女性对此效果更为敏感。进一步研究经鼻胰岛素对肥胖女性体重管理的治疗潜力是必要的。
