Department of Materials, Faculty of Science and Engineering, The University of Manchester, Manchester M13 9PL, UK; The Henry Royce Institute, Royce Hub Building, The University of Manchester, Manchester M13 9PL, UK.
Division of Cell Matrix Biology and Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.
Curr Opin Biotechnol. 2022 Jun;75:102710. doi: 10.1016/j.copbio.2022.102710. Epub 2022 Apr 7.
Non-healing wounds have led to a soaring clinical and socioeconomical need for advanced wound-care techniques. Electrical stimulation is an emerging therapy inspired by the wound's endogenous electric field. Promising results of clinical trials have encouraged efforts to create wearable stimulation devices, uncover multiple cellular targets, and optimize stimulation regimes. However, the field faces a translational bottleneck. This review aims to highlight the gaps between in vivo treatments and in vitro associated experiments by discussing the current knowledge of the generation, characterization, and targets of electrical stimuli. It becomes clear that enabling the translation of this technology will require increasing the complexity of the current models for skin endogenous and controlled ion transport, and investigating which stimulus has an optimum effect on cells derived from chronic wound-prone patients.
未愈合的伤口导致对先进伤口护理技术的临床和社会经济需求飙升。电刺激是一种新兴的治疗方法，灵感来自于伤口的内源性电场。临床试验的有希望的结果鼓励了创造可穿戴刺激设备、揭示多个细胞靶点和优化刺激方案的努力。然而，该领域面临着转化瓶颈。本综述旨在通过讨论电刺激的产生、特性和靶点的当前知识，突出体内治疗与体外相关实验之间的差距。很明显，要实现这项技术的转化，就需要增加当前皮肤内源性和控制离子传输模型的复杂性，并研究哪种刺激对来自慢性易发性伤口患者的细胞有最佳效果。
