血清分泌卷曲相关蛋白 5 的循环水平在多囊卵巢综合征中降低。
Circulating level of serum secreted frizzled-related protein 5 decreases in polycystic ovary syndrome.
机构信息
Department of Obstetrics and Gynecology, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.
Bursa Doruk Yildirim Hospital, Bursa, Turkey.
出版信息
Biomarkers. 2022 Jul;27(5):483-487. doi: 10.1080/1354750X.2022.2064549. Epub 2022 Apr 19.
OBJECTIVES
To analyse the SFRP-5 serum levels in PCOS and to investigate the relationship between SFRP-5 and other metabolic parameters in PCOS.
MATERIAL AND METHODS
This is a prospective case-control study carried out in a research hospital. A total of 88 subjects including 43 patients diagnosed PCOS according to Rotterdam criteria and age -BMI matched 45 healthy controls were evaluated. Serum SFRP5, fasting blood glucose, insulin levels and HOMA-IR scores of the groups were determined and compared. The cut-off of SFRP-5 for detecting PCOS was calculated.
RESULTS
Serum SFRP-5 levels were lower in PCOS group compared to the controls (290.13 ± 187.66 ng/mL vs 533.03 ± 208.55 ng/mL, < 0.001). There was no correlation in the PCOS group regarding SFRP-5 and other parameters. The role of SFRP-5 to predict the PCOS risk was assessed with receiver operating curve (ROC). The sensitivity of SFRP-5 was 74.4% and the specificity was 75.6% at a threshold ≤388.38 ng/ml in PCOS.
CONCLUSION
SFRP-5 could be a beneficial marker for PCOS diagnosis, follow-up and treatment.
目的
分析多囊卵巢综合征（PCOS）患者血清 SFRP-5 水平，并探讨其与 PCOS 患者其他代谢参数的关系。
材料与方法
这是在一家研究医院进行的前瞻性病例对照研究。共评估了 88 名受试者，包括 43 名根据鹿特丹标准诊断为 PCOS 的患者和 45 名年龄 -BMI 匹配的健康对照者。测定并比较了各组血清 SFRP5、空腹血糖、胰岛素水平和 HOMA-IR 评分。计算了 SFRP-5 检测 PCOS 的截断值。
结果
与对照组相比，PCOS 组血清 SFRP-5 水平较低（290.13±187.66ng/mL 比 533.03±208.55ng/mL，<0.001）。在 PCOS 组中，SFRP-5 与其他参数之间无相关性。采用受试者工作特征曲线（ROC）评估 SFRP-5 预测 PCOS 风险的作用。SFRP-5 阈值≤388.38ng/ml 时，对 PCOS 的敏感性为 74.4%，特异性为 75.6%。
结论
SFRP-5 可能是 PCOS 诊断、随访和治疗的有益标志物。
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