Mathai David S, Mora Victoria, Garcia-Romeu Albert
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
School of Health Professions, Baylor College of Medicine, Houston, TX, United States.
Front Psychol. 2022 Mar 25;13:868103. doi: 10.3389/fpsyg.2022.868103. eCollection 2022.
Ketamine is a dissociative drug that has been used medically since the 1970s primarily as an anesthetic agent but also for various psychiatric applications. Anecdotal reports and clinical research suggest substantial potential for ketamine as a treatment in conjunction with psychological interventions. Here, we review historical and modern approaches to the use of ketamine with psychotherapy, discuss the clinical relevance of ketamine's acute psychoactive effects, propose a unique model for using esketamine (one isomeric form of ketamine) with Acceptance and Commitment Therapy (ACT), and suggest considerations for moving medication-assisted psychotherapy forward as a field.
氯胺酮是一种分离性药物，自20世纪70年代以来一直在医学上使用，主要用作麻醉剂，但也用于各种精神科应用。轶事报道和临床研究表明，氯胺酮与心理干预相结合作为一种治疗方法具有巨大潜力。在此，我们回顾了氯胺酮与心理治疗结合使用的历史和现代方法，讨论了氯胺酮急性精神活性作用的临床相关性，提出了一种将艾司氯胺酮（氯胺酮的一种异构体形式）与接纳与承诺疗法（ACT）结合使用的独特模型，并提出了推动药物辅助心理治疗作为一个领域向前发展的考虑因素。
