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2
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Identification of Potential Prognostic Long Non-Coding RNA Biomarkers for Predicting Recurrence in Patients with Cervical Cancer.用于预测宫颈癌患者复发的潜在预后长链非编码RNA生物标志物的鉴定
Cancer Manag Res. 2020 Jan 31;12:719-730. doi: 10.2147/CMAR.S231796. eCollection 2020.
4
LINC00958 facilitates cervical cancer cell proliferation and metastasis by sponging miR-625-5p to upregulate LRRC8E expression.LINC00958 通过海绵吸附 miR-625-5p 来上调 LRRC8E 表达，从而促进宫颈癌细胞增殖和转移。
J Cell Biochem. 2020 Mar;121(3):2500-2509. doi: 10.1002/jcb.29472. Epub 2019 Nov 5.
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miR-625 reverses multidrug resistance in gastric cancer cells by directly targeting ALDH1A1.微小RNA-625通过直接靶向醛脱氢酶1A1逆转胃癌细胞的多药耐药性。
Cancer Manag Res. 2019 Jul 15;11:6615-6624. doi: 10.2147/CMAR.S208708. eCollection 2019.
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lncRNA-PDPK2P promotes hepatocellular carcinoma progression through the PDK1/AKT/Caspase 3 pathway.长链非编码 RNA-PDPK2P 通过 PDK1/AKT/Caspase 3 通路促进肝癌进展。
Mol Oncol. 2019 Oct;13(10):2246-2258. doi: 10.1002/1878-0261.12553. Epub 2019 Aug 22.
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Sci Rep. 2019 Jul 24;9(1):10718. doi: 10.1038/s41598-019-47218-0.
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Olive Leaf Extract Attenuates Inflammatory Activation and DNA Damage in Human Arterial Endothelial Cells.橄榄叶提取物减轻人动脉内皮细胞中的炎症激活和DNA损伤。
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A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis.一种新型长链非编码 RNA MCM3AP-AS1 通过靶向 miR-194-5p/FOXA1 轴促进肝癌的生长。
Mol Cancer. 2019 Feb 19;18(1):28. doi: 10.1186/s12943-019-0957-7.
10
LINC00852 Promotes Lung Adenocarcinoma Spinal Metastasis by Targeting S100A9.LINC00852 通过靶向 S100A9 促进肺腺癌脊髓转移。
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LINC00852通过miR-625/E2F1轴调控肝细胞癌的细胞增殖、侵袭、迁移和凋亡。

LINC00852 Regulates Cell Proliferation, Invasion, Migration and Apoptosis in Hepatocellular Carcinoma the miR-625/E2F1 Axis.

作者信息

Chen Shi

机构信息

Department of Pathology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, No. 283, Tongzipo Road, Yuelu District, Changsha, 410013 Hunan People's Republic of China.

出版信息

Cell Mol Bioeng. 2021 Dec 3;15(2):207-217. doi: 10.1007/s12195-021-00714-8. eCollection 2022 Apr.

DOI:10.1007/s12195-021-00714-8
PMID:35401844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8938543/
Abstract

OBJECTIVE

This study investigates the function and regulatory mechanism of lncRNA LINC00852 in hepatocellular carcinoma (HCC) cells.

METHODS

The effects of LINC00852 and E2F1 on HCC cell proliferation, invasion, migration and apoptosis were measured by MTT assay, Transwell invasion and migration assays and TUNEL staining, respectively. The apoptosis of HCC cells was further determined by the expression levels of apoptosis-related proteins (Bax and Bcl2). Dual-luciferase reporter assays verified the targeting relationships among LINC00852, miR-625 and E2F1.

RESULTS

Overexpression of LINC00852 was positively associated with HCC cell proliferation, invasion and migration while negatively associated with the cell apoptosis. LINC00852 bound miR-625 which further targeted E2F1. Overexpressing miR-625 or down-regulating E2F1 reversed the oncogenic effects of LINC00852.

CONCLUSION

LINC00852 regulates HCC cell activities the miR-625/E2F1 axis.

摘要

目的

本研究探讨长链非编码RNA LINC00852在肝癌（HCC）细胞中的功能及调控机制。

方法

分别采用MTT法、Transwell侵袭和迁移实验以及TUNEL染色检测LINC00852和E2F1对肝癌细胞增殖、侵袭、迁移及凋亡的影响。通过凋亡相关蛋白（Bax和Bcl2）的表达水平进一步确定肝癌细胞的凋亡情况。双荧光素酶报告基因实验验证了LINC00852、miR-625和E2F1之间的靶向关系。

结果

LINC00852的过表达与肝癌细胞的增殖、侵袭和迁移呈正相关，而与细胞凋亡呈负相关。LINC00852与miR-625结合，miR-625进一步靶向E2F1。过表达miR-625或下调E2F1可逆转LINC00852的致癌作用。

结论

LINC00852通过miR-625/E2F1轴调节肝癌细胞活性。