Jiang Tianlin, Wang Yanli, Wang Xiaohong, Xu Jun
Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, China.
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Front Neurosci. 2022 Aug 18;16:988265. doi: 10.3389/fnins.2022.988265. eCollection 2022.
CHCHD2 and CHCHD10 are homolog mitochondrial proteins that play key roles in the neurological, cardiovascular, and reproductive systems. They are also involved in the mitochondrial metabolic process. Although previous research has concentrated on their functions within mitochondria, their functions within apoptosis, synaptic plasticity, cell migration as well as lipid metabolism remain to be concluded. The review highlights the different roles played by CHCHD2 and/or CHCHD10 binding to various target proteins (such as OPA-1, OMA-1, PINK, and TDP43) and reveals their non-negligible effects in cognitive impairments and motor neuron diseases. This review focuses on the functions of CHCHD2 and/or CHCHD10. This review reveals protective effects and mechanisms of CHCHD2 and CHCHD10 in neurodegenerative diseases characterized by cognitive and motor deficits, such as frontotemporal dementia (FTD), Lewy body dementia (LBD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). However, there are numerous specific mechanisms that have yet to be elucidated, and additional research into these mechanisms is required.
CHCHD2和CHCHD10是同源线粒体蛋白，在神经、心血管和生殖系统中发挥关键作用。它们也参与线粒体代谢过程。尽管先前的研究集中在它们在线粒体内的功能，但它们在细胞凋亡、突触可塑性、细胞迁移以及脂质代谢中的功能仍有待确定。这篇综述强调了CHCHD2和/或CHCHD10与各种靶蛋白（如OPA-1、OMA-1、PINK和TDP43）结合所起的不同作用，并揭示了它们在认知障碍和运动神经元疾病中的不可忽视的影响。这篇综述聚焦于CHCHD2和/或CHCHD10的功能。这篇综述揭示了CHCHD2和CHCHD10在以认知和运动缺陷为特征的神经退行性疾病中的保护作用和机制，如额颞叶痴呆（FTD）、路易体痴呆（LBD）、帕金森病（PD）和肌萎缩侧索硬化症（ALS）。然而，仍有许多具体机制有待阐明，需要对这些机制进行更多研究。
