Ghafouri-Fard Soudeh, Hussen Bashdar Mahmud, Mohaqiq Mahdi, Shoorei Hamed, Baniahmad Aria, Taheri Mohammad, Jamali Elena
Department of Medical Genetics, School of Medicine, Shahid Beheshti Universality of Medical Sciences, Tehran, Iran.
Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
Front Oncol. 2022 Mar 23;12:808475. doi: 10.3389/fonc.2022.808475. eCollection 2022.
Programmed cell death (PDCD) family of proteins includes at least 12 members, function of seven of them being more investigated. These members are PDCD1, PDCD2, PDCD4, PDCD5, PDCD6, PDCD7 and PDCD10. Consistent with the important roles of these proteins in the regulation of apoptosis, dysregulation of PDCDs is associated with diverse disorders ranging from intervertebral disc degeneration, amyotrophic lateral sclerosis, immune thrombocytopenia, type 1 diabetes, congenital hypothyroidism, Alzheimer's disease to different types of cancers. More recently, the interaction between non-coding RNAs and different members of PDCD family is being discovered. In the current study, we described the functional interactions between PDCDs and two classes of non-coding RNAs, namely microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). miR-21 and miR-183 are two miRNAs whose interactions with PDCDs have been assessed in different contexts. The lncRNAs interaction with PDCDs is mainly assessed in the context of neoplasia indicating the role of MALAT1, MEG3, SNHG14 and LINC00473 in this process.
程序性细胞死亡（PDCD）蛋白家族至少包括12个成员，其中7个成员的功能得到了更深入的研究。这些成员分别是PDCD1、PDCD2、PDCD4、PDCD5、PDCD6、PDCD7和PDCD10。鉴于这些蛋白在细胞凋亡调控中的重要作用，PDCD家族失调与多种疾病相关，包括椎间盘退变、肌萎缩侧索硬化症、免疫性血小板减少症、1型糖尿病、先天性甲状腺功能减退症、阿尔茨海默病以及不同类型的癌症。最近，人们发现了非编码RNA与PDCD家族不同成员之间的相互作用。在本研究中，我们描述了PDCD家族与两类非编码RNA，即微小RNA（miRNA）和长链非编码RNA（lncRNA）之间的功能相互作用。miR-21和miR-183是两种已在不同背景下评估了其与PDCD家族相互作用的miRNA。lncRNA与PDCD家族的相互作用主要在肿瘤形成背景下进行评估，表明了MALAT1、MEG3、SNHG14和LINC00473在此过程中的作用。
