Dillon H C, Khare S, Gray B M
J Pediatr. 1987 Jan;110(1):31-6. doi: 10.1016/s0022-3476(87)80283-4.
A prospective study of group B streptococcal (GBS) carriage and disease was conducted over 6 years. Carriage rates at delivery for mothers and infants were 20% and 12%, respectively. Forty-five cases of GBS disease occurred in infants, 24 "early-onset" disease and 21 "late-onset" disease. The combined attack rate for early and late disease was 3.3 per 1000 live births over the 6 years. The rate of early-onset disease was highest in infants found to be heavily colonized at birth: 50 per 1000 live births. Twenty-three of 24 had evidence of intrauterine-acquired infection. All GBS serotypes were represented. Preterm delivery, prolonged labor, premature rupture of membranes, and maternal infection enhanced the risk of early disease. Septicemia was the predominant form of late-onset disease (15 of 21 cases); GBS type III accounted for 19 of 21 cases. Ten of 21 infants with late infections were colonized at birth with the GBS type that subsequently caused disease. Thus a maternal source of infection was identified in 34 of the 45 infants. These data reveal consistent year-to-year carriage and disease rates in the study population.
一项关于B族链球菌（GBS）携带情况和疾病的前瞻性研究持续了6年。母亲和婴儿在分娩时的携带率分别为20%和12%。婴儿中发生了45例GBS疾病，其中24例为“早发型”疾病，21例为“晚发型”疾病。在这6年中，早发型和晚发型疾病的合并发病率为每1000例活产中有3.3例。早发型疾病的发病率在出生时被发现大量定植的婴儿中最高：每1000例活产中有50例。24例中有23例有宫内感染的证据。所有GBS血清型均有出现。早产、产程延长、胎膜早破和母亲感染增加了早发型疾病的风险。败血症是晚发型疾病的主要形式（21例中有15例）；III型GBS占21例中的19例。21例晚发型感染的婴儿中有10例在出生时被随后导致疾病的GBS血清型定植。因此，在45例婴儿中有34例确定了感染的母体来源。这些数据揭示了研究人群中逐年一致的携带率和发病率。
