Lung Nodule Malignancy Prediction From Longitudinal CT Scans With Siamese Convolutional Attention Networks.

We propose a convolutional attention-based network that allows for use of pre-trained 2-D convolutional feature extractors and is extendable to multi-time-point classification in a Siamese structure. Our proposed framework is evaluated for single- and multi-time-point classification to explore the value that temporal information, such as nodule growth, adds to malignancy prediction. Our results show that the proposed method outperforms a comparable 3-D network with less than half the parameters on single-time-point classification and further achieves performance gains on multi-time-point classification. Attention-based, Siamese 2-D pre-trained CNNs lead to fast training times and are effective for malignancy prediction from single-time-point or multiple-time-point imaging data.