Department of Neurology, Hubei University of Medicine, Shiyan City, Hubei Province, China.
Department of Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan City, Hubei Province, China.
Int J Neurosci. 2021 Mar;131(3):283-288. doi: 10.1080/00207454.2020.1738428. Epub 2020 Mar 31.
Stroke is one of the major diseases that endanger the physical health life of middle-aged and old people. It has the characteristics of high incidence, mortality and disability rate. Atherosclerosis is the main intervention target for stroke prevention and treatment. MiRNAs are highly expressed in the cerebral vasculature and play an important regulatory role in the pathogenesis of neuronal damage and ischemic stroke. This article reviews the mechanism of action between miRNAs and atherosclerosis, stroke, ischemia-reperfusion injury, collateral circulation and circRNA molecular networks, providing theoretical support for miRNA in gene diagnosis and drug therapy of atherosclerotic stroke.
中风是危害中老年人身体健康生命的主要疾病之一，具有发病率、死亡率和致残率高的特点。动脉粥样硬化是中风预防和治疗的主要干预靶点。miRNAs 在脑血管中高度表达，在神经元损伤和缺血性中风的发病机制中发挥重要的调节作用。本文综述了 miRNAs 与动脉粥样硬化、中风、缺血再灌注损伤、侧支循环和 circRNA 分子网络之间的作用机制，为 miRNA 在动脉粥样硬化性中风的基因诊断和药物治疗方面提供了理论支持。
