Waikato Regional Cancer Centre, Waikato Hospital, Pembroke Street, Hamilton, Waikato, 3204, New Zealand.
Phys Eng Sci Med. 2022 Jun;45(2):577-587. doi: 10.1007/s13246-022-01123-5. Epub 2022 Apr 11.
The aim of this study was to present our experience on clinical implementation of HyperArc including dosimetric comparison between VMAT and HyperArc plans and dosimetric verification of HyperArc. In this study, eleven previously treated cases of brain metastasis were selected from our brain stereotactic radiotherapy program. The cases were retrospectively planned using HyperArc technique and the plan quality was evaluated. In addition, dosimetric effects of HyperArc plan with different energies and using jaw tracking technique were evaluated. Furthermore, dosimetric verification of HyperArc plans was performed using ion chamber and radiochromic film. Our results of dosimetric comparison shows that HyperArc technique improved both conformity index and gradient index compared to VMAT plans. We also found that using 6MV flattening filter free (6MV-FFF) beam improves gradient index in HyperArc plans compared to using 6MV flattening filter beam. Furthermore, our results show that jaw tracking technique reduces the size of low dose volume while maintaining similar target coverage, conformity index, and gradient index. In our dosimetric verification study, results of ion chamber and film measurement indicate no significant difference between VMAT and HyperArc plans. In conclusion, HyperArc simplifies planning of stereotactic treatment for brain and improves the dosimetry in treatment plans. Additionally, HyperArc provides for a safe and efficient treatment delivery system for stereotactic treatments to brain.
本研究旨在介绍我们在 HyperArc 临床应用方面的经验,包括 VMAT 和 HyperArc 计划的剂量学比较以及 HyperArc 的剂量学验证。在本研究中,我们从我们的脑部立体定向放疗计划中选择了 11 例先前治疗的脑转移病例。这些病例采用 HyperArc 技术进行回顾性计划,并评估了计划质量。此外,还评估了不同能量的 HyperArc 计划和使用 jaw tracking 技术的剂量学效果。此外,还使用电离室和光致变色胶片对 HyperArc 计划进行了剂量学验证。我们的剂量学比较结果表明,与 VMAT 计划相比,HyperArc 技术提高了适形指数和梯度指数。我们还发现,与使用 6MV 均整滤波器(6MV-FFF)光束相比,使用 6MV 无均整滤波器光束可提高 HyperArc 计划的梯度指数。此外,我们的结果表明,jaw tracking 技术可减小低剂量体积,同时保持相似的靶区覆盖、适形指数和梯度指数。在我们的剂量学验证研究中,电离室和胶片测量的结果表明 VMAT 和 HyperArc 计划之间没有显著差异。总之,HyperArc 简化了脑部立体定向治疗的计划,并改善了治疗计划的剂量学。此外,HyperArc 为脑部的立体定向治疗提供了安全有效的治疗输送系统。