Department of Genetics and Genome Biology, University of Leicester, University Road, Leicester LE1 7RH, UK.
School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
Microbiology (Reading). 2022 Apr;168(4). doi: 10.1099/mic.0.001162.
Bacteria have evolved mechanisms which enable them to control intracellular concentrations of metals. In the case of transition metals, such as copper, iron and zinc, bacteria must ensure enough is available as a cofactor for enzymes whilst at the same time preventing the accumulation of excess concentrations, which can be toxic. Interestingly, metal homeostasis and resistance systems have been found to play important roles in virulence. This review will discuss the copper homeostasis and resistance systems in and and the implications that acquisition of additional copper resistance genes may have in these pathogens.
细菌已经进化出了一些机制，使它们能够控制金属在细胞内的浓度。对于过渡金属，如铜、铁和锌，细菌必须确保有足够的金属作为酶的辅因子，同时防止过量金属的积累，因为过量的金属可能是有毒的。有趣的是，金属动态平衡和抗性系统已被发现对毒力起着重要作用。这篇综述将讨论 和 中的铜动态平衡和抗性系统，以及这些病原体获得额外的铜抗性基因可能产生的影响。
